A New Lead Identification Strategy: Screening an sp3‐rich and Lead‐like Compound Library Composed of 7‐Azanorbornane Derivatives
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201900398
Abstract: Although the advantages of sp3‐rich, sterically complicated molecules in drug development have been pointed out, modern screening libraries are filled with planar, sp2‐rich components. Compounds that are sp3‐rich are difficult to synthesize, and thus we… read more here.
Keywords: sp3; lead identification; lead like; sp3 rich ... See more keywords
C(sp3)−H Arylation Promoted by a Heterogeneous Palladium‐N‐Heterocyclic Carbene Complex in Batch and Continuous Flow
Sign Up to like & getrecommendations! Published in 2022 at "Chemsuschem"
DOI: 10.1002/cssc.202102736
Abstract: Abstract A heterogeneous reusable palladium(II)‐bis(N‐heterocyclic carbene) catalyst was prepared and shown to catalyze the intramolecular C(sp3)−H activation/cyclization of N‐alkyl‐2‐bromoanilines furnishing indolines. This new catalytic system was based on a bis‐imidazolium ligand immobilized on a spaced… read more here.
Keywords: sp3; continuous flow; palladium; heterocyclic carbene ... See more keywords
Catalytic diastereoselective and enantioconvergent C(sp3)—C(sp3) cross-coupling of racemic partners
Sign Up to like & getrecommendations! Published in 2020 at "Science China Chemistry"
DOI: 10.1007/s11426-020-9745-1
Abstract: Carbon-carbon bond formation is the core of organic synthesis. Transition metal-catalyzed cross-coupling reaction between organohalides and organometallic reagents is one of the most important and straightforward methods for construction of C–C bonds. The catalytic cross… read more here.
Keywords: sp3; bond; carbon centers; cross ... See more keywords
Low temperature, pressureless sp2 to sp3 transformation of ultrathin, crystalline carbon films
Sign Up to like & getrecommendations! Published in 2019 at "Carbon"
DOI: 10.1016/j.carbon.2019.01.017
Abstract: Nanosized and crystalline sp3-bonded carbon materials were prepared over large surface areas up to ∼33 × 51 μm2 from the exposure of few-layer graphene (FLG) to H radicals produced by the hot-filament process at low temperature (below 325 °C)… read more here.
Keywords: temperature pressureless; crystalline; sp3; low temperature ... See more keywords
Aerobic iron-catalyzed site-selective C(sp3)–C(sp3) bond cleavage in N-heterocycles
Sign Up to like & getrecommendations! Published in 2021 at "Catalysis Communications"
DOI: 10.1016/j.catcom.2021.106333
Abstract: Abstract The kinetic and thermodynamic stability of C(sp3)–C(sp3) bonds makes the site-selective activation of these motifs a real synthetic challenge. In view of this, herein a site-selective method of C(sp3)–C(sp3) bond scission of amines, specifically… read more here.
Keywords: sp3 sp3; sp3; site selective; sp3 bond ... See more keywords
Wustite-induced formation of sp3-rich faceted carbon foam: The key role of cooling rate on sp3-abundance (and oxide crystal-habit) control
Sign Up to like & getrecommendations! Published in 2018 at "Materials today communications"
DOI: 10.1016/j.mtcomm.2018.06.014
Abstract: Abstract We report the formation of a novel faceted carbon-foam (CFM) phase by re-crystallization of recently discovered sp3-rich α−Fe filled CFM. The formation of this novel carbon material is found by increasing the cooling-rate factor after… read more here.
Keywords: crystal habit; faceted carbon; sp3; carbon ... See more keywords
Reactor core analysis through the SP3-ACMFD approach. Part I: Static solution
Sign Up to like & getrecommendations! Published in 2020 at "Nuclear Engineering and Technology"
DOI: 10.1016/j.net.2019.07.022
Abstract: Abstract The present work proposes a solution to the static Boltzmann transport equation approximated by the simplified P3 (SP3) on angular, and the analytic coarse mesh finite difference (ACMFD) for spatial variables. Multi-group SP3-ACMFD equations… read more here.
Keywords: sp3 acmfd; transport; approach; sp3 ... See more keywords
Pd-catalyzed imine-directed intramolecular C N bond formation through C(sp3) H activation: An efficient approach to multisubstituted pyrroles
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.151887
Abstract: Abstract An atom-economic approach to synthesize 1,2,4-trisubstituted pyrroles through palladium-catalyzed imine-directed intramolecular C(sp3) H amination reaction has been developed. The imine group acts as a directing group as well as an intramolecular nucleophile for the… read more here.
Keywords: sp3; imine directed; approach; directed intramolecular ... See more keywords
Sulfonamide as Photoinduced Hydrogen-Atom Transfer Catalyst for Regioselective Alkylation of C(sp3)-H Bonds Adjacent to Heteroatoms.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c03992
Abstract: Based on the DFT calculations, the sulfonamide was explored as an efficient hydrogen-atom transfer catalyst for the C(sp3)-H alkylation. The combination of a metal-free photoredox catalyst and a sulfonamide catalyst enables highly regioselective alkylation of… read more here.
Keywords: atom transfer; sp3; hydrogen atom; alkylation ... See more keywords
Photoredox/Nickel Dual Catalysis Enables the Synthesis of Alkyl Cyclopropanes via C(sp3)-C(sp3) Cross Electrophile Coupling of Unactivated Alkyl Electrophiles.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04268
Abstract: A facile synthesis of mono-, 1,1- and 1,2-disubstituted cyclopropanes via visible light-mediated photoredox/nickel dual catalysis is demonstrated. The challenging intramolecular C(sp3)-C(sp3) cross-electrophile coupling of readily available unactivated 1,3-dialkyl electrophiles was performed under mild conditions that… read more here.
Keywords: sp3; dual catalysis; photoredox nickel; cyclopropanes via ... See more keywords
Nickel-Catalyzed C(sp3)-C(sp3) Cross-Electrophile Coupling of In Situ Generated NHP Esters with Unactivated Alkyl Bromides.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00805
Abstract: The formation of C(sp3)-C(sp3) bonds by cross-coupling remains a challenge in synthesis. Here, we demonstrate a two-step, one-pot protocol for the in situ generation of N-hydroxyphthalimide esters and their nickel-catalyzed cross-electrophile coupling with unactivated alkyl… read more here.
Keywords: unactivated alkyl; nickel catalyzed; sp3; sp3 sp3 ... See more keywords