A General Strategy for C(sp3)─H Bond Etherification via Quinoline Derivative‐Mediated Electrolysis
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DOI: 10.1002/advs.202416803
Abstract: Electrooxidative coupling of C(sp3)─H bonds with nucleophiles offers an attractive method for constructing C─C and C─X bonds without sacrificial oxidants. However, the direct electrochemical approach requires the nucleophilic reagent to have a higher potential than… read more here.
Keywords: bond etherification; sp3; strategy; quinoline derivative ... See more keywords
Energy Transfer Enabled Radical Deoxygenative C(sp3)‐N Construction
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DOI: 10.1002/cctc.202500317
Abstract: The formation of C(sp3)‐N bonds constitutes a pivotal transformation in functional molecule synthesis, with conventional methods predominantly relying on polar substitution paradigms. To address the inherent limitations of existing approaches, we report a radical‐mediated strategy… read more here.
Keywords: sp3; energy transfer; transfer enabled; enabled radical ... See more keywords
C(sp3)‒H Activation of Alcohol for C(sp3)‒C(sp3) Bond Formation via Heterogeneous Photocatalysis in Flow
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DOI: 10.1002/cctc.202500894
Abstract: C(sp3)‒H activation of alcohols enables creating new C─C bond while keeping hydroxyl group in a step and atom economic manner. Here, we disclose a protocol of coupling alcohols with alkenes for C(sp3)‒C(sp3) bond formation via… read more here.
Keywords: sp3; bond; photocatalysis flow; heterogeneous photocatalysis ... See more keywords
A New Lead Identification Strategy: Screening an sp3‐rich and Lead‐like Compound Library Composed of 7‐Azanorbornane Derivatives
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DOI: 10.1002/cmdc.201900398
Abstract: Although the advantages of sp3‐rich, sterically complicated molecules in drug development have been pointed out, modern screening libraries are filled with planar, sp2‐rich components. Compounds that are sp3‐rich are difficult to synthesize, and thus we… read more here.
Keywords: sp3; lead identification; lead like; sp3 rich ... See more keywords
C(sp3)−H Arylation Promoted by a Heterogeneous Palladium‐N‐Heterocyclic Carbene Complex in Batch and Continuous Flow
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DOI: 10.1002/cssc.202102736
Abstract: Abstract A heterogeneous reusable palladium(II)‐bis(N‐heterocyclic carbene) catalyst was prepared and shown to catalyze the intramolecular C(sp3)−H activation/cyclization of N‐alkyl‐2‐bromoanilines furnishing indolines. This new catalytic system was based on a bis‐imidazolium ligand immobilized on a spaced… read more here.
Keywords: sp3; continuous flow; palladium; heterocyclic carbene ... See more keywords
N‐Directed defluorinative γ‐C(sp3)−H allylation of sulfamate esters for synthesis of gem‐difluoroalkenes via photoredox catalysis
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202400011
Abstract: gem‐Difluoroalkenes are unique structural motifs with important applications ranging from drugs to materials. Herein, we report a novel radical‐mediated defluorinative allylation of sulfamate esters with α‐trifluoromethyl alkenes through distal C(sp3)−H functionalization under photoredox conditions. The reaction… read more here.
Keywords: sp3; gem difluoroalkenes; allylation sulfamate; gem ... See more keywords
Neutral sp2‐sp3 Diboranes: Structures, Reactivities, and Applications in Organic Synthesis
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DOI: 10.1002/ejoc.202500223
Abstract: Neutral sp2‐sp3 diboranes are characterized by a polarized B–B single bond between two electronically and structurally distinct boryl groups, featuring one sp2‐hybridized (three‐coordinate) boron center and one sp3‐hybridized (four‐coordinate) boron center with a neutral Lewis… read more here.
Keywords: sp3; chemistry; sp2; sp2 sp3 ... See more keywords
Catalytic diastereoselective and enantioconvergent C(sp3)—C(sp3) cross-coupling of racemic partners
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DOI: 10.1007/s11426-020-9745-1
Abstract: Carbon-carbon bond formation is the core of organic synthesis. Transition metal-catalyzed cross-coupling reaction between organohalides and organometallic reagents is one of the most important and straightforward methods for construction of C–C bonds. The catalytic cross… read more here.
Keywords: sp3; bond; carbon centers; cross ... See more keywords
Low temperature, pressureless sp2 to sp3 transformation of ultrathin, crystalline carbon films
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DOI: 10.1016/j.carbon.2019.01.017
Abstract: Nanosized and crystalline sp3-bonded carbon materials were prepared over large surface areas up to ∼33 × 51 μm2 from the exposure of few-layer graphene (FLG) to H radicals produced by the hot-filament process at low temperature (below 325 °C)… read more here.
Keywords: temperature pressureless; crystalline; sp3; low temperature ... See more keywords
Aerobic iron-catalyzed site-selective C(sp3)–C(sp3) bond cleavage in N-heterocycles
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DOI: 10.1016/j.catcom.2021.106333
Abstract: Abstract The kinetic and thermodynamic stability of C(sp3)–C(sp3) bonds makes the site-selective activation of these motifs a real synthetic challenge. In view of this, herein a site-selective method of C(sp3)–C(sp3) bond scission of amines, specifically… read more here.
Keywords: sp3 sp3; sp3; site selective; sp3 bond ... See more keywords
Wustite-induced formation of sp3-rich faceted carbon foam: The key role of cooling rate on sp3-abundance (and oxide crystal-habit) control
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DOI: 10.1016/j.mtcomm.2018.06.014
Abstract: Abstract We report the formation of a novel faceted carbon-foam (CFM) phase by re-crystallization of recently discovered sp3-rich α−Fe filled CFM. The formation of this novel carbon material is found by increasing the cooling-rate factor after… read more here.
Keywords: crystal habit; faceted carbon; sp3; carbon ... See more keywords