Elemental‐Sulfur‐Promoted C(sp3)−H Activation of Methyl Heteroarenes Leading to Thioamides
Sign Up to like & getrecommendations! Published in 2017 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.201700532
Abstract: A novel approach to access bioactive thioamides is developed based on elemental sulfur promoted C(sp3)-H activation of methyl heteroarenes. This transformation could successfully furnish a series of heterocyclic thioamides with excellent yields and it could… read more here.
Keywords: methyl heteroarenes; sp3 activation; sulfur promoted; promoted sp3 ... See more keywords
Palladium Catalysis Enabled Sequential C(sp3)-H/C-C Activation: Access to Vinyl γ-Lactams.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c00710
Abstract: A Pd(II)-catalyzed tandem reaction of aliphatic amides with vinylcyclopropanes (VCPs) was accomplished by merging C(sp3)-H and C-C activation. The reaction of VCP revealed alkenylation/cyclization, followed by ring opening via C-C cleavage, delivering vinyl γ-lactams with… read more here.
Keywords: vinyl lactams; enabled sequential; catalysis enabled; palladium catalysis ... See more keywords
Pd-Catalyzed Cascade Heck/C(sp3)-H Activation for Spirocyclopropyl Oxindoles.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c01017
Abstract: We have demonstrated a Pd(0)-catalyzed Heck/C(sp3)-H activation cascade for the synthesis of spirocyclopropyl oxindoles in high yields from easily accessible ortho-bromoacrylamides. The formation of spirocyclopropyl oxindole is guided by an unconventional four-membered palladacycle through C(sp3)-H… read more here.
Keywords: spirocyclopropyl oxindoles; sp3 activation; heck sp3; sp3 ... See more keywords
Palladium/Benzoic Acid-Catalyzed Regio- and Stereoselective Polymerization of Internal Diynes and Diols through C(sp3)–H Activation
Sign Up to like & getrecommendations! Published in 2019 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.9b00448
Abstract: The C–H activation has been a hot research area in organic chemistry, and the most difficult one is the C(sp3)–H activation. Although the C–H activation has been introduced to the research of synthetic polymer chemistry,… read more here.
Keywords: activation; sp3 activation; benzoic acid; polymerization ... See more keywords
sp3 C–H activation via exo-type directing groups
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Science"
DOI: 10.1039/c7sc04768a
Abstract: The application of exo-type directing groups (DGs) has led to the discovery of a wide range of novel C(sp3)–H activation methods, which allow efficient and site-selective functionalization of alcohol and amide derivatives. read more here.
Keywords: exo type; type directing; directing groups; sp3 activation ... See more keywords
Transition metal-catalyzed sp3 C-H activation and intramolecular C-N coupling to construct nitrogen heterocyclic scaffolds.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc06609h
Abstract: Nitrogen heterocycles are of great medicinal importance, and the construction of nitrogen heterocyclic scaffolds has been one of the focuses in synthetic organic chemistry. Recently, the strategy of transition metal-catalyzed sp3 C-H activation and intramolecular… read more here.
Keywords: nitrogen; transition metal; heterocyclic scaffolds; nitrogen heterocyclic ... See more keywords
Selective propargylic C(sp3)–H activation of methyl-substituted alkynes versus [2 + 2] cycloaddition at a titanium imido template
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DOI: 10.1039/d1sc04334j
Abstract: The reaction of the titanium imido complex 1b with 2-butyne leads to the formation of the titanium azadiene complex 2a at ambient temperature instead of yielding the archetypical [2 + 2] cycloaddition product (titanaazacyclobutene) which… read more here.
Keywords: titanium imido; cycloaddition; propargylic sp3; titanium ... See more keywords
Metal-Free C(sp3)–Si Activation Enables Regiocontrolled [4+2] Cycloaddition to Benzosilacycloethers
Sign Up to like & getrecommendations! Published in 2025 at "Green Chemistry"
DOI: 10.1039/d5gc03044g
Abstract: We herein report a sustainable, transition-metal-free strategy for the inverse site-selective [4+2] cycloaddition of benzosilacyclobutanes with activated ketones, enabled by the dual role of DMSO as a mild Lewis base... read more here.
Keywords: enables regiocontrolled; metal free; cycloaddition; sp3 activation ... See more keywords
Advances and developments in transition metal-free benzylic C(sp3)–H activation/functionalization reactions
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DOI: 10.1039/d5ra00361j
Abstract: Transition metal-free C(sp3)–H activation of toluene derivatives is known as a green and sustainable methodology for constructing carbon–carbon and carbon–heteroatom bonds. Benzylic C(sp3)–H activation/functionalization bond formation can be carried out in the presence of organic/inorganic… read more here.
Keywords: sp3 activation; transition metal; activation functionalization; activation ... See more keywords
Direct C(sp3)–H Activation of Carboxylic Acids
Sign Up to like & getrecommendations! Published in 2019 at "Synthesis"
DOI: 10.1055/s-0039-1690720
Abstract: Carboxylic acids are important in a variety of research fields and applications. As a result, substantial efforts have been directed towards the C–H functionalization of such compounds. While the use of the carboxylic acid moiety… read more here.
Keywords: activation carboxylic; carboxylic acids; aliphatic carboxylic; sp3 activation ... See more keywords