Cp*Rh(III)-catalyzed C(sp3) H alkenylation and arylation of 8-methylquinolines with quinones and thiophenes
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DOI: 10.1016/j.catcom.2019.05.008
Abstract: Abstract Rh(III)-catalyzed oxidative cross-coupling of C(sp3) H bonds with C(sp2) H bonds has been accomplished under mild conditions. This method furnishes a streamlined route for the C(sp3) H alkenylation and arylation of 8-methylquinolines. This protocol… read more here.
Keywords: sp3 alkenylation; iii catalyzed; alkenylation arylation; arylation methylquinolines ... See more keywords
C(sp3)-H Alkenylation of Tetrahydroisoquinolines via Merging Electrochemistry and Organocatalysis.
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DOI: 10.1021/acs.orglett.2c04136
Abstract: C(sp3)-H alkenylation of tetrahydroisoquinoline by merging Shono oxidation and the Morita-Baylis-Hillman reaction is developed, employing 4-dimethylaminopyridine as an organocatalyst and TEMPO/NaBr as an electrocatalyst. The reaction proceeds via the interception of an iminium cation intermediate,… read more here.
Keywords: sp3 alkenylation; reaction; electrochemistry; tetrahydroisoquinolines via ... See more keywords
Electrochemical Enantioselective Nucleophilic α-C(sp3)-H Alkenylation of 2-Acyl Imidazoles.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c01686
Abstract: Merging electrochemistry with asymmetric catalysis promises to provide an environmentally friendly and efficient strategy for the construction of nonracemic chiral molecules. However, in practice, significant challenges arise from the instability or incompatibility of the chiral… read more here.
Keywords: sp3 alkenylation; nucleophilic sp3; acyl imidazoles; enantioselective nucleophilic ... See more keywords
Access to hexahydroazepinone heterocycles via palladium-catalysed C(sp3)-H alkenylation/ring-opening of cyclopropanes.
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DOI: 10.1039/d2cc01917e
Abstract: In this communication, we describe the synthesis of novel hexahydroazepinone derivatives starting from two simple building blocks in presence of a readily available palladium catalyst. The reaction proceeds through a selective C(sp3)-H alkenylation/ring-opening process to… read more here.
Keywords: hexahydroazepinone; alkenylation ring; sp3 alkenylation; palladium ... See more keywords
Synthesis of allylanilines via scandium-catalysed benzylic C(sp3)-H alkenylation with alkynes.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02489f
Abstract: The ortho-selective benzylic C(sp3)-H alkenylation of 2-methyl tertiary anilines with internal alkynes has been achieved for the first time by using a half-sandwich scandium catalyst. This protocol provides a straightforward route for the synthesis of… read more here.
Keywords: sp3 alkenylation; benzylic sp3; scandium; synthesis ... See more keywords