Mild C(sp3)‒H Alkylation of 8-Methylquinolines with α,β-Unsaturated Carbonyl Compounds by Rhodium(III) Catalysis
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DOI: 10.1002/ajoc.201700261
Abstract: A straightforward approach to the synthesis of γ-quinolyl carbonyl compounds has been presented via rhodium(III)-catalyzed C(sp3)-H alkylation of 8-methyquinolines with conjugated C＝C multiple bonds. Remarkably, this C(sp3)-H functionalization proceeds under mild reaction conditions, obviates the… read more here.
Keywords: alkylation methylquinolines; carbonyl compounds; sp3 alkylation; mild sp3 ... See more keywords
A Germanium Catalyst Accelerates the Photoredox α-C(sp3)-H Alkylation of Primary Amines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00871
Abstract: Site-selective C(sp3)-H functionalizations using photoredox catalysis (PC) and hydrogen atom transfer (HAT) catalysis have received increasing attention. Here, we report a Ph2GeCl2 cocatalyst that greatly improves the yield of α-C(sp3)-H alkylation of primary amines catalyzed… read more here.
Keywords: catalyst accelerates; germanium catalyst; alkylation primary; sp3 alkylation ... See more keywords
Decatungstate-Catalyzed C(sp3)-H Alkylation of a Val Residue Proximal to the N-Terminus Controlled by an Electrostatic Interaction.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01154
Abstract: The decatungstate photocatalyst [W10O32]4- efficiently promoted the C(sp3)-H alkylation of the trifluoroacetic acid salt of valine methyl ester (H-Val-OMe·TFA) with electron-deficient alkenes under UV irradiation. The electrostatic interaction between the cationic ammonium group (+NH3) of… read more here.
Keywords: electrostatic interaction; alkylation; val residue; val ... See more keywords
Benzaldehyde- and Nickel-Catalyzed Photoredox C(sp3)-H Alkylation/Arylation with Amides and Thioethers.
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DOI: 10.1021/acs.orglett.9b02226
Abstract: Herein a synergistic combination of a nickel catalyst and benzaldehyde for the utilization of amides and thioethers in C(sp3)-H alkylation and arylation reactions employing simple aryl or alkyl halides is reported. This method provides a… read more here.
Keywords: alkylation arylation; amides thioethers; sp3 alkylation; benzaldehyde nickel ... See more keywords
tBuOK/DMSO/O2 Catalyzed direct α-C(sp3)-H Alkylation with Styrenes: productive α-amino radical for hydroaminoalkylation
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DOI: 10.1039/d2qo01911f
Abstract: Direct α-C(sp3)-H alkylation of hydroaminoalkylation (HAA) catalyzed by tBuOK/DMSO/O2 from α-aryl benzylamines with styrenes is reported. The reaction has delivered diverse selectively substituted amines and N-heterocycles under mild conditions, showing... read more here.
Keywords: sp3 alkylation; direct sp3; hydroaminoalkylation; tbuok dmso ... See more keywords