Iron-Phosphine Complex-Catalyzed Intramolecular C(sp3)-H Amination of Azides.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00308
Abstract: Fe(II)-phosphine complex [Fe(dpbz)]Cl2 was demonstrated to be effective for the intramolecular C(sp3)-H amination of organic azides. This catalyst exhibited a high catalytic capacity for the transformations from α-azido amides to imidazolinones. Cyclization of simple aliphatic… read more here.
Keywords: intramolecular sp3; phosphine complex; sp3 amination;
Synthesis of 1,2-Fused/Disubstituted Benzimidazoles and Benzimidazolium Salts by I2-Mediated sp3 C-H Amination.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03630
Abstract: An intramolecular sp3 C-H amination reaction of aniline derivatives has been established. This reaction employs molecular iodine (I2) under transition-metal-free conditions and produces 1,2-fused or 1,2-disubstituted benzimidazoles. This operationally simple synthetic process works well with… read more here.
Keywords: disubstituted benzimidazoles; sp3 amination; fused disubstituted; benzimidazoles benzimidazolium ... See more keywords
Cu-Catalyzed C(sp3) Amination of Unactivated Secondary Alkyl Iodides Promoted by Diaryliodonium Salts.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01216
Abstract: Herein, we describe the development of a copper-catalyzed C(sp3) amination of unactivated secondary alkyl iodides mediated by diaryliodonium salts. Our protocol is enabled by the intermediacy of aryl radical species that undergo halogen atom transfer… read more here.
Keywords: sp3 amination; alkyl iodides; amination unactivated; catalyzed sp3 ... See more keywords
Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp3)-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium
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DOI: 10.1021/acsomega.0c04865
Abstract: An electrochemical synthesis for quinazolines and quinazolinones was developed via a C(sp3)-H amination/C-N cleavage by virtue of the anodic oxidation. The reaction can be carried out in aqueous media under mild conditions to afford the… read more here.
Keywords: sp3 amination; amination cleavage; oxidation; quinazolines quinazolinones ... See more keywords
Catalytic Synthesis of N-Heterocycles via Direct C(sp3)–H Amination Using an Air-Stable Iron(III) Species with a Redox-Active Ligand
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b00270
Abstract: Coordination of FeCl3 to the redox-active pyridine–aminophenol ligand NNOH2 in the presence of base and under aerobic conditions generates FeCl2(NNOISQ) (1), featuring high-spin FeIII and an NNOISQ radical ligand. The complex has an overall S… read more here.
Keywords: direct sp3; air stable; redox active; ligand ... See more keywords
Approach to pactamycin analogues using rhodium(II)-catalyzed alkene aziridination and C(sp3)–H amination reactions
Sign Up to like & getrecommendations! Published in 2018 at "Organic chemistry frontiers"
DOI: 10.1039/c7qo00878c
Abstract: Dirhodium(II)-catalyzed nitrene transfers have been used to prepare a novel synthetic platform bearing the triamino moiety present in pactamycin, jogyamycin and cranomycin. Catalytic intramolecular C(sp3)–H amination and alkene aziridination reactions, the latter followed by a… read more here.
Keywords: alkene aziridination; pactamycin; sp3 amination;
Silver(i)-mediated oxidative C(sp3)–H amination of ethers with azole derivatives under mild conditions
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DOI: 10.1039/c9qo00644c
Abstract: A silver(i)-mediated oxidative N–H/C(sp3)–H coupling of NH-azoles with ethers has been developed. read more here.
Keywords: amination ethers; oxidative sp3; sp3 amination; silver mediated ... See more keywords
Stereoselective synthesis of trans-aziridines via intramolecular oxidative C(sp3)–H amination of β-amino ketones
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DOI: 10.1039/c9qo01489f
Abstract: Aziridines are ubiquitous in bioactive molecules and often serve as key synthetic building blocks. We report herein an intramolecular KI/TBHP mediated oxidative dehydrogenative C(sp3)–H amination reaction to synthesize a diverse array of trans-2,3-disubstituted aziridines in… read more here.
Keywords: synthesis trans; stereoselective synthesis; sp3; sp3 amination ... See more keywords
Copper-catalyzed oxidative benzylic C(sp3)-H amination: direct synthesis of benzylic carbamates.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc05226d
Abstract: A new efficient strategy to access benzylic carbamates through C-H activation is reported. The use of a catalytic amount of a Cu(i)/diimine ligand in combination with NFSI ((PhSO2)2NF) or F-TEDA-PF6 as oxidants and H2NCO2R as… read more here.
Keywords: benzylic carbamates; oxidative benzylic; copper catalyzed; benzylic sp3 ... See more keywords