Fe-Catalyzed Sequential C(sp3)-H/N-H Annulation of 2-Methylindoles with Ethyl Trifluoropyruvate at Room Temperature: Construction of Pyrrolo[1,2-α]indoles.
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DOI: 10.1021/acs.orglett.0c01522
Abstract: An efficient and benign iron-catalyzed room-temperature method was developed for direct sequential C(sp3)-H/N-H annulation to construct pyrroloindole scaffolds. This strategy features cheap and readily available raw materials and mild room-temperature reaction conditions and provides a… read more here.
Keywords: sp3 annulation; sequential sp3; room temperature; pyrrolo indoles ... See more keywords
Ligand-Controlled Alkylation–Heck–C(sp3)–H Annulation Cascade for a Divergent Synthesis of Cyclobutane- and Cyclopropane-Containing Heterocycles
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c11047
Abstract: The ability to harness divergent reactivity and selectively dictate product outcomes from simple precursors has been a longstanding challenge in organic chemistry. Specifically, the realization of this goal in C–H functionalization remains a considerable challenge… read more here.
Keywords: annulation; annulation cascade; sp3 annulation; ligand controlled ... See more keywords