Microwave‐Promoted Metal‐Free α‐Alkylation of Ketones with Cycloalkanes through Cross‐Coupling of C(sp3)−H Bonds
Sign Up to like & getrecommendations! Published in 2017 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.201700256
Abstract: A MWI-promoted α-alkylation of ketones by using cycloalkanes as the alkylating agents under metal-free conditions is presented. Mechanistically, this alkylation involves a TBP-initiated and MWI-assisted formation of the required cycloalkyl radical and the α-ketone carbon… read more here.
Keywords: coupling sp3; sp3 bonds; alkylation; metal free ... See more keywords
Photochemical Carboxylation of Activated C(sp3 )-H Bonds with CO2.
Sign Up to like & getrecommendations! Published in 2017 at "ChemSusChem"
DOI: 10.1002/cssc.201700205
Abstract: From ugly duckling to beautiful C1: Although CO2 may represent an ideal C1 source, it is challenging to use it as a raw material and direct carboxylation with CO2 has mainly been confined to highly… read more here.
Keywords: bonds co2; photochemical carboxylation; sp3 bonds; activated sp3 ... See more keywords
Research on correlation of mechanical behavior of multilayer in-plane graphene/hexagonal boron nitride heterostructures in the presence of Stone-Wales defects and interlayer sp3 bonds with multiple physical fields
Sign Up to like & getrecommendations! Published in 2020 at "Computational Materials Science"
DOI: 10.1016/j.commatsci.2020.109974
Abstract: Abstract The integration of vertical and in-plane heterostructures will generate unexpected structures that may trigger novel physical properties. By introducing interlayer sp3 bonds, the multilayer in-plane graphene/h-BN heterostructures are gradually changed to “quasi three-dimensional” structure.… read more here.
Keywords: plane graphene; interlayer sp3; multilayer plane; sp3 bonds ... See more keywords
Ferric nitrate-catalyzed aerobic oxidation of benzylic sp3 CH bonds of ethers and alkylarenes
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.04.011
Abstract: A simple catalytic oxidation system was developed for the selective aerobic oxidation of structurally diverse benzylic sp3 CH bonds of ethers and alkylarenes. The reactions were performed with Fe(NO3)3·9H2O as the catalyst, KPF6 as the… read more here.
Keywords: ethers alkylarenes; oxidation; benzylic sp3; sp3 bonds ... See more keywords
2-(Pyridin-2-yl)isopropyl (PIP) Amine: An Enabling Directing Group for Divergent and Asymmetric Functionalization of Unactivated Methylene C(sp3)-H Bonds.
Sign Up to like & getrecommendations! Published in 2021 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.1c00168
Abstract: ConspectusDirecting group (DG) assistance provides a good solution to the problems of reactivity and selectivity, two of the fundamental challenges in C(sp3)-H activation. However, the activation of unbiased methylene C(sp3)-H bonds remains challenging due to… read more here.
Keywords: pip amine; methylene sp3; group; sp3 bonds ... See more keywords
Synthesis of Unnatural α-Amino Acid Derivatives via Photoredox Activation of Inert C(sp3)-H Bonds.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01822
Abstract: The synthesis of unnatural, tertiary amino acids is a challenging task. While decarboxylation-radical addition has been an important strategy for their formation, the use of alkyl radicals from C(sp3)-H bonds has not been fully explored.… read more here.
Keywords: synthesis unnatural; sp3 bonds; amino acid; unnatural amino ... See more keywords
Rhodium(III)-Catalyzed Acylation of C(sp3)-H Bonds with Cyclopropenones.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b01650
Abstract: Rh(III)-catalyzed activation and acylation of sp3 C-H bonds has been realized with diarylcyclopropenone as an acylating reagent. Both benzylic C-H in 8-methylquinolines and unactivated C-H in 2-alkylpyridines are applicable in this C-H acylation reaction, providing… read more here.
Keywords: acylation sp3; acylation; iii catalyzed; sp3 bonds ... See more keywords
Nickel-Catalyzed Cross-Dehydrogenative Coupling of α-C(sp3)-H Bonds in N-Methylamides with C(sp3)-H Bonds in Cyclic Alkanes.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b02736
Abstract: A nickel-catalyzed cross-dehydrogenative coupling reaction of α-C(sp3)-H bonds in N-methylamides with C(sp3)-H bonds from cyclic alkanes has been developed, which offers a cheap transition-metal-catalyzed C-H activation method for amides without the requirement for any extraneous… read more here.
Keywords: bonds methylamides; cross dehydrogenative; sp3 bonds; dehydrogenative coupling ... See more keywords
Homo- and Heteroannulation of sp3 C-H Bonds in Acetophenones for Divergent Synthesis of Thienothiazoles.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03414
Abstract: A synthesis of fused thieno[3,2-d]thiazoles via direct functionalization of C(sp3)-H bonds in acetophenones was reported. The transformation is divergent to afford either 2-phenylbenzo[4,5]thieno[3,2-d]thiazoles or benzo[4,5]thieno[3,2-d]thiazol-2-yl(phenyl)methanones. Cross-coupling of acetophenones with C-H bonds in phenylacetic acids, methylazaarenes,… read more here.
Keywords: homo heteroannulation; sp3 bonds; heteroannulation sp3; bonds acetophenones ... See more keywords
Intramolecular Pd-Catalyzed Reductive Amination of Enolizable sp3-C-H Bonds.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03458
Abstract: A palladium-catalyzed reductive cyclization of nitroarenes has been designed to construct sp3-C-NHAr bonds from sp3-C-H bonds by using an enolizable nucleophile to intercept a nitrosoarene intermediate. Exposure of ortho-substituted nitroarenes to 5 mol % of Pd(OAc)2… read more here.
Keywords: intramolecular catalyzed; catalyzed reductive; sp3 bonds; reductive amination ... See more keywords
Vanadium(VIV)-Porphyrin-Based Metal-Organic Frameworks for Synergistic Bimetallic Activation of Inert C(sp3)-H Bonds.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c20420
Abstract: Activation and selective functionalization of inert C(sp3)-H bonds remain one of the most challenging tasks in current synthetic chemistry. Herein, by decorating vanadium(VIV)-porphyrin into metal-organic frameworks (MOFs) to stabilize the active tertbutyl peroxide radical, we… read more here.
Keywords: sp3 bonds; viv porphyrin; inert sp3; activation ... See more keywords