Synergistic Copper‐Aminocatalysis for Direct Tertiary α‐Alkylation of Ketones with Electron‐Deficient Alkanes
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202402255
Abstract: In this study, a novel approach for the tertiary α‐alkylation of ketones using alkanes with electron‐deficient C─H bonds is presented, employing a synergistic catalytic system combining inexpensive copper salts with aminocatalysis. This methodology addresses the… read more here.
Keywords: tertiary alkylation; alkylation ketones; electron deficient; copper ... See more keywords
Defluorinative Cyclization of Enamides with Fluoroalkyl Halides Through Two Vicinal C(sp3)─F Bonds Functionalization
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DOI: 10.1002/advs.202404738
Abstract: Introducing distinctive functional groups to expand the structural diversity and improve the intrinsic properties of parent molecules has been an essential pursuit in organic chemistry. By using perfluoroalkyl halide (PFAH) as a nontraditional, readily available,… read more here.
Keywords: cyclization enamides; cyclization; sp3 bonds; defluorinative cyclization ... See more keywords
Microwave‐Promoted Metal‐Free α‐Alkylation of Ketones with Cycloalkanes through Cross‐Coupling of C(sp3)−H Bonds
Sign Up to like & getrecommendations! Published in 2017 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.201700256
Abstract: A MWI-promoted α-alkylation of ketones by using cycloalkanes as the alkylating agents under metal-free conditions is presented. Mechanistically, this alkylation involves a TBP-initiated and MWI-assisted formation of the required cycloalkyl radical and the α-ketone carbon… read more here.
Keywords: coupling sp3; sp3 bonds; alkylation; metal free ... See more keywords
Photochemical Carboxylation of Activated C(sp3 )-H Bonds with CO2.
Sign Up to like & getrecommendations! Published in 2017 at "ChemSusChem"
DOI: 10.1002/cssc.201700205
Abstract: From ugly duckling to beautiful C1: Although CO2 may represent an ideal C1 source, it is challenging to use it as a raw material and direct carboxylation with CO2 has mainly been confined to highly… read more here.
Keywords: bonds co2; photochemical carboxylation; sp3 bonds; activated sp3 ... See more keywords
Engineering Redox-Active Metal Sites into Covalent Organic Frameworks for Efficient Photocatalytic Activation and Aerobic Oxidation of C(sp3)─H Bonds.
Sign Up to like & getrecommendations! Published in 2025 at "Small"
DOI: 10.1002/smll.202505887
Abstract: Partial oxidation of alkanes with green O2 source for valuable oxygenated products is one of the most challenging tasks in chemistry due to the difficulty of the activation of both inert C(sp3)─H bonds and unreactive… read more here.
Keywords: covalent organic; activation; organic frameworks; metal ... See more keywords
Research on correlation of mechanical behavior of multilayer in-plane graphene/hexagonal boron nitride heterostructures in the presence of Stone-Wales defects and interlayer sp3 bonds with multiple physical fields
Sign Up to like & getrecommendations! Published in 2020 at "Computational Materials Science"
DOI: 10.1016/j.commatsci.2020.109974
Abstract: Abstract The integration of vertical and in-plane heterostructures will generate unexpected structures that may trigger novel physical properties. By introducing interlayer sp3 bonds, the multilayer in-plane graphene/h-BN heterostructures are gradually changed to “quasi three-dimensional” structure.… read more here.
Keywords: plane graphene; interlayer sp3; multilayer plane; sp3 bonds ... See more keywords
Ferric nitrate-catalyzed aerobic oxidation of benzylic sp3 CH bonds of ethers and alkylarenes
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.04.011
Abstract: A simple catalytic oxidation system was developed for the selective aerobic oxidation of structurally diverse benzylic sp3 CH bonds of ethers and alkylarenes. The reactions were performed with Fe(NO3)3·9H2O as the catalyst, KPF6 as the… read more here.
Keywords: ethers alkylarenes; oxidation; benzylic sp3; sp3 bonds ... See more keywords
2-(Pyridin-2-yl)isopropyl (PIP) Amine: An Enabling Directing Group for Divergent and Asymmetric Functionalization of Unactivated Methylene C(sp3)-H Bonds.
Sign Up to like & getrecommendations! Published in 2021 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.1c00168
Abstract: ConspectusDirecting group (DG) assistance provides a good solution to the problems of reactivity and selectivity, two of the fundamental challenges in C(sp3)-H activation. However, the activation of unbiased methylene C(sp3)-H bonds remains challenging due to… read more here.
Keywords: pip amine; methylene sp3; group; sp3 bonds ... See more keywords
Synthesis of Unnatural α-Amino Acid Derivatives via Photoredox Activation of Inert C(sp3)-H Bonds.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01822
Abstract: The synthesis of unnatural, tertiary amino acids is a challenging task. While decarboxylation-radical addition has been an important strategy for their formation, the use of alkyl radicals from C(sp3)-H bonds has not been fully explored.… read more here.
Keywords: synthesis unnatural; sp3 bonds; amino acid; unnatural amino ... See more keywords
Borylation of Stable C(sp3)-O Bonds of Alkyl Esters over Supported Au Catalysts.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c00225
Abstract: We report herein that supported gold catalysts efficiently promote the borylation of stable C(sp3)-O bonds of alkyl esters. The use of a disilane as an electron source and gold nanoparticles as a single-electron transfer catalyst… read more here.
Keywords: alkyl esters; bonds alkyl; esters supported; stable sp3 ... See more keywords
Remote Functionalization of Inert C(sp3)-H Bonds via Dual Catalysis Driven by Alkene Hydrofluoroalkylation Using Industrial Feedstocks.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c02901
Abstract: We have developed a dual-catalytic system capable of site-selective azidation of inert C(sp3)-H bonds with concomitant and modular anti-Markovnikov alkene fluoroalkylation. The protocol leverages the synergetic cooperation of both the photocatalyst and earth-abundant iron catalyst… read more here.
Keywords: bonds via; remote functionalization; functionalization inert; sp3 bonds ... See more keywords