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Published in 2017 at "Science"
DOI: 10.1126/science.aan1411
Abstract: Trifluoromethylation via broken C-F bonds Trifluoromethyl substituents are widely used in pharmaceutical research to tune the properties of drug candidates. Generally, they are introduced intact through the formation of carbon-carbon bonds. Levin et al. discovered…
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Keywords:
mechanism;
bond;
fluoride rebound;
sp3 cf3 ... See more keywords