Copper-Catalyzed Functionalization of Aza-Aromatic Rings with Fluoroalcohols via Direct C(sp2)-H/C(sp3)-H Coupling Reactions.
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DOI: 10.1021/acs.orglett.0c00797
Abstract: An efficient copper-catalyzed direct C(sp2)-H/C(sp3)-H coupling reaction of aza-aromatic rings with fluoroalcohols is developed. A variety of useful building blocks including hydroxyfluoroalkylated aniline, pyrrole, and indole derivatives bearing a quaternary carbon center could be constructed… read more here.
Keywords: sp2 sp3; sp3 coupling; aromatic rings; direct sp2 ... See more keywords
Radical C(sp3)-S Coupling for the Synthesis of α-Amino Sulfides.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01121
Abstract: A unique transition-metal-free radical thiolation of 2-azaallyl anions has been developed. Easily accessible thiosulfonates and 2-azaallyls undergo the tandem process of single-electron transfer and radical-radical coupling to construct C(sp3)-S bonds. This robust protocol enables a… read more here.
Keywords: sp3 coupling; coupling synthesis; amino sulfides; radical sp3 ... See more keywords
Copper-Catalyzed C(sp)-C(sp3) Coupling of Terminal Alkynes with Alkylsilyl Peroxides via a Radical Mechanism.
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DOI: 10.1021/acs.orglett.8b00173
Abstract: A copper-catalyzed C(sp)-C(sp3) coupling reaction between terminal alkynes and alkylsilyl peroxides is reported. In the presence of a copper catalyst and 4-dimethylaminopyridine, the reaction smoothly affords a variety of internal alkynes by coupling alkylsilyl peroxides… read more here.
Keywords: sp3 coupling; catalyzed sp3; alkylsilyl peroxides; terminal alkynes ... See more keywords
Micelle-Enabled Palladium Catalysis for Convenient sp2-sp3 Coupling of Nitroalkanes with Aryl Bromides in Water Under Mild Conditions
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DOI: 10.1021/acscatal.7b02663
Abstract: The efficacy of custom surfactant FI-750-M, designed to mimic polar solvents such as DMF and 1,4-dioxane, has been demonstrated with the palladium-catalyzed sp2-sp3 coupling of nitroalkanes to aryl bromides using a heteroleptic palladium catalyst under… read more here.
Keywords: sp2 sp3; sp3 coupling; aryl bromides; mild conditions ... See more keywords
NiH-catalyzed C(sp3)-Si coupling of alkenes with vinyl chlorosilanes.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc04232k
Abstract: A novel NiH-catalyzed highly regioselective coupling of alkenes with vinyl chlorosilanes, constructing C-Si bonds, is developed. Under mild reaction conditions, a series of benzyl organosilanes with various functional groups could be accessed. Further synthetic studies… read more here.
Keywords: alkenes vinyl; sp3 coupling; vinyl chlorosilanes; nih catalyzed ... See more keywords
Electrochemical intramolecular N(sp2)–H/N(sp3)–H coupling for the synthesis of 1H-indazoles
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DOI: 10.1039/d3gc00380a
Abstract: The electrochemical intramolecular cyclization of ketimines via N–H/N–H dehydrogenation coupling has been established for the construction of 1H-indazole scaffolds. read more here.
Keywords: synthesis indazoles; sp2 sp3; sp3 coupling; coupling synthesis ... See more keywords