Electrochemical Oxidative C(sp3 )-H/N-H Cross-Coupling for N-Mannich Bases with Hydrogen Evolution.
Sign Up to like & getrecommendations! Published in 2018 at "ChemSusChem"
DOI: 10.1002/cssc.201802676
Abstract: N-Mannich bases are an important structure in various functional molecules. A new protocol to synthesize N-Mannich bases was established through electrochemical external-oxidant-free C(sp3 )-H/N-H cross-coupling with hydrogen evolution. Various N-methylanilines were explored in this transformation.… read more here.
Keywords: cross coupling; hydrogen evolution; sp3 cross; mannich bases ... See more keywords
Expanding the Medicinal Chemist Toolbox: Comparing Seven C(sp2)–C(sp3) Cross-Coupling Methods by Library Synthesis
Sign Up to like & getrecommendations! Published in 2020 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.0c00093
Abstract: Despite recent advances in the field of C(sp2)–C(sp3) cross-couplings and the accompanying increase in publications, it can be hard to determine which method is appropriate for a given reaction when using the highly functionalized intermediates… read more here.
Keywords: library synthesis; sp2 sp3; chemistry; sp3 cross ... See more keywords
Nontraditional Fragment Couplings of Alcohols and Carboxylic Acids: C(sp3)-C(sp3) Cross-Coupling via Radical Sorting.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c02062
Abstract: Alcohols and carboxylic acids are among the most commercially abundant, synthetically versatile, and operationally convenient functional groups in organic chemistry. Under visible light photoredox catalysis, these native synthetic handles readily undergo radical activation, and the… read more here.
Keywords: alcohols carboxylic; cross coupling; sp3 sp3; sp3 cross ... See more keywords
Copper-catalyzed α-C–H amidation of simple ethers through C(sp3)–H/N–H cross dehydrogenative coupling
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DOI: 10.1039/c7qo01003f
Abstract: An efficient copper-catalyzed α-C–H amidation of simple ethers with N-(8-quinolyl)amides through C(sp3)–H/N–H cross dehydrogenative coupling was developed. Chelation assistance was employed for the formation of an active copper amide species which can couple with the… read more here.
Keywords: amidation simple; simple ethers; simple; catalyzed amidation ... See more keywords
Micelle enabled C(sp2)-C(sp3) cross-electrophile coupling in water via synergistic nickel and copper catalysis.
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DOI: 10.1039/d1cc02885e
Abstract: A robust and sustainable C(sp2)-C(sp3) cross-electrophile coupling was developed via nickel/copper synergistic catalysis under micellar conditions. This protocol provided a general method to access alkylated arenes with good to excellent yields on a very large… read more here.
Keywords: sp2 sp3; cross electrophile; nickel copper; sp3 cross ... See more keywords
Electrochemical α-C(sp3)-H/O-H cross-coupling of isochromans and alcohols assisted by benzoic acid.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03883h
Abstract: Isochroman moieties are present in a wide variety of biologically active molecules, but converting isochromans to α-substituted derivatives under mild conditions is challenging. Herein, we report a mild, convenient protocol for synthesis of α-alkoxy isochroman… read more here.
Keywords: cross coupling; electrochemical sp3; sp3 cross; isochromans alcohols ... See more keywords