I2-DMSO-Mediated N-H/α-C(sp3)-H Difunctionalization of Tetrahydroisoquinoline: Formal [2 + 2 + 1] Annulation for the Construction of Pyrrolo[2,1-a]isoquinoline Derivatives.
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DOI: 10.1021/acs.orglett.2c00813
Abstract: An I2-DMSO-mediated cascade reaction using methyl ketones and 1,2,3,4-tetrahydroisoquinolines (THIQs) as commercially available substrates has been developed for the construction of pyrrolo[2,1-a]isoquinoline derivatives. This metal-free process involves N-H/α-C(sp3)-H difunctionalization of THIQ. Two C-C bonds and… read more here.
Keywords: construction pyrrolo; dmso mediated; pyrrolo isoquinoline; sp3 difunctionalization ... See more keywords
Visible-Light-Induced α,γ-C(sp3)-H Difunctionalization of Piperidines.
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DOI: 10.1021/acs.orglett.2c00831
Abstract: Herein, we describe a novel protocol for visible-light-induced α,γ-C(sp3)-H difunctionalization of piperidines. This redox-neutral, atom-economical protocol, which exhibits a broad substrate scope and good functional group compatibility, constitutes a concise, practical method for constructing piperidine-containing… read more here.
Keywords: light induced; difunctionalization piperidines; sp3 difunctionalization; visible light ... See more keywords