Pd-catalyzed γ-C(sp3)-H Fluorination of Free Amines.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b13537
Abstract: The first example of free amine γ-C(sp3)-H fluorination is realized using 2-hydroxynicotinaldehyde as the transient directing group. A wide range of cyclohexyl and linear aliphatic amines could be fluorinated selectively at the γ-methyl and methylene… read more here.
Keywords: methyl fluorination; step; sp3 fluorination; fluorination ... See more keywords
Controlling Pd(IV) reductive-elimination pathways enables Pd(II)-catalyzed enantioselective C(sp3)–H fluorination
Sign Up to like & getrecommendations! Published in 2018 at "Nature chemistry"
DOI: 10.1038/s41557-018-0048-1
Abstract: The development of a Pd(ii)-catalysed enantioselective fluorination of C(sp3)−H bonds would offer a new approach to making chiral organofluorines. However, such a strategy is particularly challenging because of the difficulty in differentiating prochiral C(sp3)−H bonds… read more here.
Keywords: reductive elimination; enantioselective sp3; sp3; sp3 fluorination ... See more keywords
Ketones as directing groups in photocatalytic sp3 C–H fluorination† †Electronic supplementary information (ESI) available. CCDC 1556373, 1556374 and 1556555. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc02703f
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Science"
DOI: 10.1039/c7sc02703f
Abstract: Visible light-sensitization allows conformationally rigid ketones to act as “directing groups” for aliphatic fluorination using Selectfluor, catalytic benzil, and LEDs. read more here.
Keywords: directing groups; ketones directing; sp3 fluorination; fluorination ... See more keywords