Ligand Enabled Pd(II)-Catalyzed γ-C(sp3)-H Lactamization of Native Amides.
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DOI: 10.1021/jacs.1c10183
Abstract: γ-Lactams form important structural cores of a range of medicinally relevant natural products and clinical drugs, principal examples being the new generation of immunomodulatory imide drugs (IMiDs) and the brivaracetam family. Compared to conventional multistep… read more here.
Keywords: sp3 lactamization; enabled catalyzed; ligand enabled; catalyzed sp3 ... See more keywords