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   Articles with "sp3 rich" as a keyword



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A New Lead Identification Strategy: Screening an sp3‐rich and Lead‐like Compound Library Composed of 7‐Azanorbornane Derivatives

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recommendations! Published in 2019 at "ChemMedChem"

DOI: 10.1002/cmdc.201900398

Abstract: Although the advantages of sp3‐rich, sterically complicated molecules in drug development have been pointed out, modern screening libraries are filled with planar, sp2‐rich components. Compounds that are sp3‐rich are difficult to synthesize, and thus we… read more here.

Keywords: sp3; lead identification; lead like; sp3 rich ... See more keywords
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Reagent-Based Scaffold Diversity for DNA-Encoded Library Design: Solid Phase Synthesis of DNA-Tagged sp3-Rich Heterocycles by SnAP Chemistry.

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recommendations! Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.2c00228

Abstract: Reactions that require strictly dry conditions are challenging to translate to a DNA-encoded library format. Controlled pore glass solid support-connected DNA oligonucleotide-aldehyde conjugates could be condensed with SnAP reagents and cyclized to various sp3-rich heterocycles.… read more here.

Keywords: dna; encoded library; chemistry; sp3 rich ... See more keywords
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Emergent synthetic methods for the modular advancement of sp3-rich fragments

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recommendations! Published in 2021 at "Chemical Science"

DOI: 10.1039/d1sc00161b

Abstract: Fragment-based drug discovery is an important and increasingly reliable technology for the delivery of clinical candidates. Notably, however, sp3-rich fragments are a largely untapped resource in molecular discovery, in part due to the lack of… read more here.

Keywords: methods modular; synthetic methods; sp3 rich; emergent synthetic ... See more keywords
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Access to high value sp3-rich frameworks using photocatalyzed [2 + 2]-cycloadditions of γ-alkylidene-γ-lactams.

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recommendations! Published in 2022 at "Chemical communications"

DOI: 10.1039/d2cc03009h

Abstract: By harnessing an energy transfer process, new photocatalyzed [2 + 2]-cycloadditions occurring between γ-alkylidene-γ-lactams and unsaturated substrates have been developed. The reaction mode is particularly powerful because it leads to the formation of different high… read more here.

Keywords: high value; sp3 rich; rich frameworks; photocatalyzed cycloadditions ... See more keywords