Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin
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DOI: 10.1038/s41467-021-26571-7
Abstract: Some osteoblasts embed within bone matrix, change shape, and become dendrite-bearing osteocytes. The circuitry that drives dendrite formation during “osteocytogenesis” is poorly understood. Here we show that deletion of Sp7 in osteoblasts and osteocytes causes… read more here.
Keywords: sp7; dendrite formation; gene; sp7 target ... See more keywords
Low Expression of Selenoprotein S Modulates Osteogenic Differentiation Through Bidirectional Regulation of the SP7–HSP47/COL1A1/SPARC Axis
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DOI: 10.3390/cimb47090677
Abstract: Previous studies revealed that low expression of Selenoprotein S (SELS) could enhance osteogenic differentiation, but the underlying mechanisms remain unclear. In this study, we aimed to elucidate the role of SELS and its transcription-factor-based regulatory… read more here.
Keywords: hsp47; sp7; expression; osteogenic differentiation ... See more keywords
Regulation of Skeletal Development and Maintenance by Runx2 and Sp7
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DOI: 10.3390/ijms251810102
Abstract: Runx2 (runt related transcription factor 2) and Sp7 (Sp7 transcription factor 7) are crucial transcription factors for bone development. The cotranscription factor Cbfb (core binding factor beta), which enhances the DNA-binding capacity of Runx2 and… read more here.
Keywords: runx2 sp7; bone; sp7; factor ... See more keywords