The endoplasmic reticulum proteostasis network profoundly shapes the protein sequence space accessible to HIV envelope
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DOI: 10.1371/journal.pbio.3001569
Abstract: The sequence space accessible to evolving proteins can be enhanced by cellular chaperones that assist biophysically defective clients in navigating complex folding landscapes. It is also possible, at least in theory, for proteostasis mechanisms that… read more here.
Keywords: proteostasis; proteostasis network; sequence space; space accessible ... See more keywords