Investigation of the Click-Chemical Space for Drug Design Using ZINClick.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1209-5_1
Abstract: This chapter provides a brief overview of the applications of ZINClick virtual library. In the last years, we have investigated the click-chemical space covered by molecules containing the triazole ring and generated a database of… read more here.
Keywords: space; investigation click; space drug; drug design ... See more keywords
Expanding the Chemical Space of Drug-like Passerini Compounds: Can α-Acyloxy Carboxamides Be Considered Hard Drugs?
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DOI: 10.1021/acsmedchemlett.2c00420
Abstract: With their three points of diversity, α-acyloxy carboxamides, which are accessible with the Passerini reaction, provide heterogeneity for the preparation of libraries of putative active agents or intermediates used for the formation of more complex… read more here.
Keywords: drug like; expanding chemical; acyloxy carboxamides; hard drugs ... See more keywords
Approaches for enhancing the analysis of chemical space for drug discovery
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2084608
Abstract: ABSTRACT Introduction Chemical space is a general conceptual framework that addresses the diversity of molecules and it has various applications. Moreover, chemical space is a cornerstone of chemoinformatics. In response to the increase in the… read more here.
Keywords: drug discovery; chemical space; space; space drug ... See more keywords