Increasing the bioactive space of peptide macrocycles by thioamide substitution††Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc04671e
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DOI: 10.1039/c7sc04671e
Abstract: Thioamide substitution into macrocyclic peptides increases the conformational rigidity of the backbone resulting in enhanced biological activity and metabolic stability. read more here.
Keywords: space peptide; peptide macrocycles; bioactive space; thioamide substitution ... See more keywords
Chemical Space for Peptide-based Antimicrobials.
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DOI: 10.2533/chimia.2024.648
Abstract: Multidrug-resistant (MDR) bacteria represent a global public health threat, and antimicrobial peptides (AMPs), derived from naturally occurring linear or cyclic peptides, can provide the solution. However, most AMPs are sensitive to proteases and have poor… read more here.
Keywords: chemical space; space peptide; peptide based; space ... See more keywords