Investigation on the chemical space of the substituted triazole thio-benzoxazepinone RIPK1 inhibitors.
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DOI: 10.1016/j.ejmech.2022.114345
Abstract: As a key upstream kinase involved in the activation of necroptosis, receptor-interacting protein kinase 1 (RIPK1) plays a vital role in the treatment of relevant inflammatory diseases. Recently, we described the thio-benzoxazepinones as RIPK1 necroptosis… read more here.
Keywords: chemical space; ripk1; thio; investigation chemical ... See more keywords