The Photosensitising Clinical Agent Verteporfin Is an Inhibitor of SPAK and OSR1 Kinases
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DOI: 10.1002/cbic.201800272
Abstract: STE20/SPS1‐related proline/alanine‐rich kinase (SPAK) and oxidative‐stress‐responsive kinase 1 (OSR1) are two serine/threonine protein kinases that play key roles in regulating ion homeostasis. Various SPAK and OSR1 mouse models exhibited reduced blood pressure. Herein, the discovery of… read more here.
Keywords: agent; spak; verteporfin; osr1 kinases ... See more keywords
Structures of the Human SPAK and OSR1 Conserved C‐Terminal (CCT) Domains **
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DOI: 10.1002/cbic.202100441
Abstract: STE20/SPS1‐related proline/alanine‐rich kinase (SPAK) and oxidative stress responsive 1 (OSR1) kinase are two serine/threonine protein kinases that regulate the function of ion co‐transporters through phosphorylation. The highly conserved C‐terminal (CCT) domains of SPAK and OSR1… read more here.
Keywords: spak osr1; terminal cct; cct; human spak ... See more keywords
WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension
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DOI: 10.1038/s41401-020-0474-7
Abstract: Hypertension is the most prevalent health condition worldwide, affecting ~1 billion people. Gordon’s syndrome is a form of secondary hypertension that can arise due to a number of possible mutations in key genes that encode… read more here.
Keywords: wnk spak; kinase; treatment; osr1 ncc ... See more keywords