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   Articles with "sparc" as a keyword



SPARC promotes self‐renewal of limbal epithelial stem cells and ocular surface restoration through JNK and p38‐MAPK signaling pathways

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recommendations! Published in 2019 at "STEM CELLS"

DOI: 10.1002/stem.3100

Abstract: The purpose of this study was to investigate the effects of secreted protein acidic and rich in cysteine (SPARC) on the maintenance of limbal epithelial stem cell (LESC) stemness and restoration of ocular surface. To… read more here.

Keywords: p38 mapk; signaling pathways; sparc; jnk p38 ... See more keywords

Activity of acute pancreatitis is modified by secreted protein acidic and rich in cysteine ablation

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recommendations! Published in 2022 at "United European Gastroenterology Journal"

DOI: 10.1002/ueg2.12262

Abstract: Abstract Background Acute pancreatitis (AP) is a frequent cause for hospitalization. However, molecular determinants that modulate severity of experimental pancreatitis are only partially understood. Objective To investigate the role of secreted protein acidic and rich… read more here.

Keywords: rich cysteine; secreted protein; protein acidic; pancreatitis ... See more keywords
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Production and purification of recombinant human SPARC.

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recommendations! Published in 2018 at "Methods in cell biology"

DOI: 10.1016/bs.mcb.2017.08.020

Abstract: The matricellular protein SPARC (secreted protein acidic and rich in cysteine, also known as osteonectin or as BM-40) is a collagen-binding protein with a capacity to induce cell rounding and influence proliferation in cultured cells.… read more here.

Keywords: purification recombinant; recombinant human; sparc; recombinant sparc ... See more keywords

Secreted protein acidic and rich in cysteine (SPARC) regulates thermogenesis in white and brown adipocytes

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recommendations! Published in 2020 at "Molecular and Cellular Endocrinology"

DOI: 10.1016/j.mce.2020.110757

Abstract: SPARC, also known as osteonectin, is well known for its physiological roles in bone formation and tissue remodeling, as well as in cancer pathology; however, evidence regarding its function in adipocytes is lacking. The present… read more here.

Keywords: protein acidic; sparc; acidic rich; white brown ... See more keywords

Interplay between hevin, SPARC, and MDGAs: modulators of neurexin-neuroligin transsynaptic bridges.

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recommendations! Published in 2021 at "Structure"

DOI: 10.1016/j.str.2021.01.003

Abstract: Hevin is secreted by astrocytes and its synaptogenic effects are antagonized by the related protein, SPARC. Hevin stabilizes neurexin-neuroligin transsynaptic bridges in vivo. A third protein, membrane-tethered MDGA, blocks these bridges. Here, we reveal the molecular… read more here.

Keywords: sparc; neuroligin transsynaptic; hevin; transsynaptic bridges ... See more keywords

SPARC expression is associated with hepatic injury in rodents and humans with non-alcoholic fatty liver disease

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-18981-9

Abstract: Mechanisms that control progression from simple steatosis to steato-hepatitis and fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) are unknown. SPARC, a secreted matricellular protein, is over-expressed in the liver under chronic injury. Contribution… read more here.

Keywords: sparc; non alcoholic; sparc expression; disease ... See more keywords

SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic β cells

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-74593-w

Abstract: SPARC-deficient mice have been shown to exhibit impaired glucose tolerance and insulin secretion, but the underlying mechanism remains unknown. Here, we showed that SPARC enhanced the promoting effect of Muscarinic receptor agonist oxotremorine-M on insulin… read more here.

Keywords: sparc; secretion; insulin secretion; regulation rgs4 ... See more keywords

SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice.

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recommendations! Published in 2019 at "Clinical science"

DOI: 10.1042/cs20180714

Abstract: Obesity, metabolic syndrome, and type 2 diabetes, three strongly interrelated diseases, are associated to increased morbidity and mortality worldwide. The pathogenesis of obesity-associated disorders is still under study. Secreted protein acidic and rich in cysteine… read more here.

Keywords: mice; sparc mice; sparc; insulin ... See more keywords

Effects of exercise intensity and duration on a myokine, secreted protein acidic and rich in cysteine.

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recommendations! Published in 2021 at "European journal of sport science"

DOI: 10.1080/17461391.2021.1953152

Abstract: AbstractSecreted protein acidic and rich in cysteine (SPARC), an exercise-induced myokine, has been suggested as a potential endogenous factor that suppresses colon tumorigenesis. However, the effects of different exercise protocols on circulating SPARC levels are… read more here.

Keywords: exercise intensity; sparc; duration; effects exercise ... See more keywords

Extended-MHD simulations of disruption mitigation via massive gas injection in SPARC

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recommendations! Published in 2024 at "Nuclear Fusion"

DOI: 10.1088/1741-4326/ad9ec4

Abstract: Recent developments to the M3D-C1 code enable higher fidelity modeling of disruptions, and can be applied in the design verification of reactor-scale tokamaks. Among these new capabilities is a method to mesh conducting vessel structures… read more here.

Keywords: sparc; disruption mitigation; gas; mhd simulations ... See more keywords
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Expanding the phenotype of SPARC-related osteogenesis imperfecta: clinical findings in two patients with pathogenic variants in SPARC and literature review

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recommendations! Published in 2021 at "Journal of Medical Genetics"

DOI: 10.1136/jmedgenet-2021-107942

Abstract: Background Secreted protein, acidic, cysteine rich (SPARC)-related osteogenesis imperfecta (OI), also referred to as OI type XVII, was first described in 2015, since then there has been only one further report of this form of… read more here.

Keywords: sparc; two patients; related osteogenesis; osteogenesis imperfecta ... See more keywords