The inhibition of HeLa cells proliferation through SPARCL1 mediated by SPP1
Sign Up to like & getrecommendations! Published in 2021 at "Cytotechnology"
DOI: 10.1007/s10616-020-00443-2
Abstract: Secreted protein acidic and rich in cysteines-like 1 (SPARCL1) is implicated in tumor progression and considered as a tumor suppressor. Aim of the study is to investigate the role of SPARCL1 in the regulation of… read more here.
Keywords: overexpression; hela cells; sparcl1; proliferation ... See more keywords
Matricellular Protein SPARCL1 Regulates Blood Vessel Integrity and Antagonizes Inflammatory Bowel Disease
Sign Up to like & getrecommendations! Published in 2021 at "Inflammatory Bowel Diseases"
DOI: 10.1093/ibd/izaa346
Abstract: Abstract Background The understanding of vascular plasticity is key to defining the role of blood vessels in physiologic and pathogenic processes. In the present study, the impact of the vascular quiescence marker SPARCL1 on angiogenesis,… read more here.
Keywords: sparcl1; inflammatory bowel; vessel integrity; blood vessel ... See more keywords
Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1101/2022.04.12.488096
Abstract: Hevin is a secreted extracellular matrix protein that is encoded by the SPARCL1 gene. Recent studies have shown that Hevin plays an important role in regulating synaptogenesis and synaptic plasticity. Mutations in the SPARCL1 gene… read more here.
Keywords: hevin; endoplasmic reticulum; hand; autism ... See more keywords
SPARCL1 Is a Novel Prognostic Biomarker and Correlates with Tumor Microenvironment in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/1398268
Abstract: Background Secreted protein acidic and rich in cysteine-like 1 (SPARCL1) plays an important role in tumor pathogenesis. We aim to evaluate the clinical significance and potential biological roles of SPARCL1 in colorectal cancer (CRC). Methods… read more here.
Keywords: tumor microenvironment; expression; crc; colorectal cancer ... See more keywords
Abstract 1277: SPARCL1 exhibits different expression pattern between left- and right- sided colon cancer and it was down-regulated via DNA methylation
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-1277
Abstract: Background: We previously identified SPARC-like 1 (SPARCL1) as a suppressor for colon cancer metastasis. Recent studies confirmed its epigenetic modification in prostate cancer and osteosarcoma. Here we conducted in vivo and in vitro studies to… read more here.
Keywords: methylation; sparcl1; expression; colon cancer ... See more keywords
SPARCL1, a Novel Prognostic Predictive Factor for GI Malignancies: a Meta-Analysis
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000485584
Abstract: Background/Aims: Secreted protein acidic and rich in cysteines-like 1 (SPARCL1) is abnormally expressed in gastrointestinal (GI) malignancies. However, the correlation between SPARCL1 expression and the prognosis of patients remains unknown. Therefore, we performed a meta-analysis… read more here.
Keywords: sparcl1; predictive factor; prognostic predictive; factor malignancies ... See more keywords
Immunological role and prognostic value of SPARCL1 in pan-cancer analysis
Sign Up to like & getrecommendations! Published in 2022 at "Pathology and Oncology Research"
DOI: 10.3389/pore.2022.1610687
Abstract: Background: Secreted protein acidic and rich in cysteine-like 1 (SPARCL1) was a kind of extracellular matrix glycoprotein. SPARCL1 was strongly inhibited in most cancers. However, the potential functions of SPARCL1 in the pan-cancer cohort have… read more here.
Keywords: pan cancer; value sparcl1; sparcl1 pan; prognostic value ... See more keywords
Prognostic value of SPARCL1 in patients with colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2017.7511
Abstract: Secreted protein acidic and rich in cysteine-like 1 (SPARCL1), a member of extracelluar matrix glycoprotein, has been reported to be associated with various tumor types. The present study aimed to evaluate the prognostic value of… read more here.
Keywords: value sparcl1; sparcl1; prognostic value; sparcl1 patients ... See more keywords