Analgesic effect of coumarins from Radix angelicae pubescentis is mediated by inflammatory factors and TRPV1 in a spared nerve injury model of neuropathic pain.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2016.11.046
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Coumarins from Radix angelicae pubescentis (CRAP) are a major active component that are isolated from dried roots of Angelica biserrata Yuan et Shan, which has been used clinically to cure headaches for a… read more here.
Keywords: crap; angelicae pubescentis; spared nerve; nerve injury ... See more keywords
Crocetin attenuates spared nerve injury-induced neuropathic pain in mice.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2017.08.007
Abstract: Crocetin is the main component of saffron and exhibits anti-oxidative and anti-inflammatory effects. Neuroinflammation and oxidative stress have been recognized to play a crucial role in the pathogenesis of neuropathic pain. We investigated the effect… read more here.
Keywords: spared nerve; crocetin; sni; neuropathic pain ... See more keywords
Reversal of neuropathic pain is associated with corticostriatal functional reorganization after nerve repair in the spared nerve injury model.
Sign Up to like & getrecommendations! Published in 2022 at "Pain"
DOI: 10.1097/j.pain.0000000000002590
Abstract: ABSTRACT Following surgical repair after peripheral nerve injury, neuropathic pain diminishes in most patients, but can persist in a small proportion of cases the mechanism of which remains poorly understood. Based on the spared nerve… read more here.
Keywords: pain; spared nerve; neuropathic pain; reorganization ... See more keywords
Anxiolytic effects of hippocampal neurosteroids in normal and neuropathic rats with spared nerve injury
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.13965
Abstract: Neurosteroids are synthesized in the nervous system from cholesterol or steroidal precursors imported from peripheral sources. These compounds are important allosteric modulators of GABAA receptors, which play a vital role in modulating hippocampal functions. Chronic… read more here.
Keywords: spared nerve; anxiolytic effects; hippocampal neurosteroids; neuropathic rats ... See more keywords
PolyMorphine provides extended analgesic-like effects in mice with spared nerve injury
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Pain"
DOI: 10.1177/1744806917743479
Abstract: Morphine is a well-characterized and effective analgesic commonly used to provide pain relief to patients suffering from both acute and chronic pain conditions. Despite its widespread use and effectiveness, one of the major drawbacks of… read more here.
Keywords: spared nerve; morphine; free morphine; polymorphine ... See more keywords
A network approach to investigating the key microbes and stability of gut microbial communities in a mouse neuropathic pain model
Sign Up to like & getrecommendations! Published in 2020 at "BMC Microbiology"
DOI: 10.1186/s12866-020-01981-7
Abstract: Background Neuropathic pain is an abnormally increased sensitivity to pain, especially from mechanical or thermal stimuli. To date, the current pharmacological treatments for neuropathic pain are still unsatisfactory. The gut microbiota reportedly plays important roles… read more here.
Keywords: spared nerve; induced neuropathic; injury induced; neuropathic pain ... See more keywords
Differential Impact of miR-21 on Pain and Associated Affective and Cognitive Behavior after Spared Nerve Injury in B7-H1 ko Mouse
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00219
Abstract: MicroRNAs (miRNAs) are increasingly recognized as regulators of immune and neuronal gene expression and are potential master switches in neuropathic pain pathophysiology. miR-21 is a promising candidate that may link the immune and the pain… read more here.
Keywords: spared nerve; mir; pain; expression ... See more keywords