Nucleation of Huntingtin Aggregation Proceeds via Conformational Conversion of Pre‐Formed, Sparsely‐Populated Tetramers
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DOI: 10.1002/advs.202309217
Abstract: Pathogenic huntingtin exon‐1 protein (httex1), characterized by an expanded polyglutamine tract located between the N‐terminal amphiphilic region and a C‐terminal polyproline‐rich domain, forms fibrils that accumulate in neuronal inclusion bodies, and is associated with a… read more here.
Keywords: sparsely populated; fibril formation; conversion pre; aggregation ... See more keywords