Stable Signal Peptides and the Response to Secretion Stress in Staphylococcus aureus
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DOI: 10.1128/mbio.01507-17
Abstract: ABSTRACT Protein secretion is essential, but how it is managed is poorly understood. In bacteria, most secreted proteins require release from the outer surface of the cytoplasmic membrane by type I signal peptidase (SPase), which… read more here.
Keywords: staphylococcus aureus; secretion; spase; signal peptides ... See more keywords
Spc1 regulates the signal peptidase-mediated processing of membrane proteins
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DOI: 10.1242/jcs.258936
Abstract: ABSTRACT Signal peptidase (SPase) cleaves the signal sequences (SSs) of secretory precursors. It contains an evolutionarily conserved membrane protein subunit, Spc1, that is dispensable for the catalytic activity of SPase and whose role remains unknown.… read more here.
Keywords: spase; membrane proteins; spc1; signal peptidase ... See more keywords
Non-Specific Signal Peptidase Processing of Extracellular Proteins in Staphylococcus aureus N315
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DOI: 10.3390/proteomes11010008
Abstract: Staphylococcus aureus is one of the major community-acquired human pathogens, with growing multidrug-resistance, leading to a major threat of more prevalent infections to humans. A variety of virulence factors and toxic proteins are secreted during… read more here.
Keywords: signal peptidase; processing; peptidase; spase ... See more keywords