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   Articles with "spastin" as a keyword



Spastin Contributes to Neural Development through the Regulation of Microtubule Dynamics in the Primary Cilia of Neural Stem Cells

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recommendations! Published in 2019 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2019.05.024

Abstract: Spastin is a microtubule-severing enzyme encoded by SPAST, which is broadly expressed in various cell types originated from multiple organs. Even though SPAST is well known as a regulator of the axon growth and arborization… read more here.

Keywords: microtubule; stem cells; spastin; brain ... See more keywords

A Major Disease-Related Point Mutation in Spastin Dramatically Alters the Dynamics and Allostery of the Motor.

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recommendations! Published in 2025 at "Biochemistry"

DOI: 10.1021/acs.biochem.4c00693

Abstract: Spastin is a microtubule-severing AAA+ ATPase that is highly expressed in neuronal cells and plays a crucial role in axonal growth, branching, and regeneration. This machine oligomerizes into hexamers in the presence of ATP and… read more here.

Keywords: dynamics allostery; major disease; mutation; spastin ... See more keywords

Targeting MDM2 affects spastin protein levels and functions: implications for HSP treatment

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recommendations! Published in 2025 at "Cell Death Discovery"

DOI: 10.1038/s41420-025-02333-y

Abstract: Spastin is a microtubule (MT) severing enzyme that regulates several cell functions associated with MT dynamics. A reduction in spastin protein levels is responsible for approximately 40% of cases of Hereditary Spastic Paraplegia (HSP), a… read more here.

Keywords: levels functions; treatment; spastin protein; spastin ... See more keywords

Spastin mutations impair coordination between lipid droplet dispersion and reticulum

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recommendations! Published in 2020 at "PLoS Genetics"

DOI: 10.1371/journal.pgen.1008665

Abstract: Lipid droplets (LD) are affected in multiple human disorders. These highly dynamic organelles are involved in many cellular roles. While their intracellular dispersion is crucial to ensure their function and other organelles-contact, underlying mechanisms are… read more here.

Keywords: reticulum; mutations impair; spastin; dispersion ... See more keywords

Phosphorylation of Spastin Promotes the Surface Delivery and Synaptic Function of AMPA Receptors

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recommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"

DOI: 10.3389/fncel.2022.809934

Abstract: Synaptic plasticity is essential for cognitive functions such as learning and memory. One of the mechanisms involved in synaptic plasticity is the dynamic delivery of AMPA receptors (AMPARs) in and out of synapses. Mutations of… read more here.

Keywords: spastin; ampa receptors; phosphorylation spastin; promotes surface ... See more keywords

Suppression of spastin Mutant Phenotypes by Pak3 Loss Implicates a Role for Reactive Glia in AD-HSP

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recommendations! Published in 2020 at "Frontiers in Neuroscience"

DOI: 10.3389/fnins.2020.00912

Abstract: Neurodegenerative mechanisms due to mutations in spastin currently center on neuronal defects, primarily in microtubule and endomembrane regulation. Spastin loss in Drosophila larvae compromises neuronal microtubule distribution, alters synaptic bouton morphology, and weakens synaptic transmission… read more here.

Keywords: spastin mutant; neuronal defects; spastin; role ... See more keywords