Distinct promoter methylation profile reveals spatial epigenetic heterogeneity in 2 myeloma patients with multifocal extramedullary relapses
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DOI: 10.1186/s13148-018-0597-6
Abstract: Spatial and subclonal genetic heterogeneity in multiple myeloma (MM) have been demonstrated by sequencing of plasma cells from multi-focal regions, but studies of spatial epigenetic heterogeneity are scanty. Herein, promoter methylation status of genes implicated… read more here.
Keywords: methylation; heterogeneity; promoter methylation; epigenetic heterogeneity ... See more keywords