Spatial genome organization, TGFβ, and biomolecular condensates: Do they talk during development?
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200145
Abstract: Cis‐regulatory elements govern gene expression programs to determine cell identity during development. Recently, the possibility that multiple enhancers are orchestrated in clusters of enhancers has been suggested. How these elements are arranged in the 3D… read more here.
Keywords: development; spatial genome; tgf biomolecular; organization tgf ... See more keywords
Comparative analysis of 2D and 3D distance measurements to study spatial genome organization.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2017.01.007
Abstract: The spatial organization of genomes is non-random, cell-type specific, and has been linked to cellular function. The investigation of spatial organization has traditionally relied extensively on fluorescence microscopy. The validity of the imaging methods used… read more here.
Keywords: distance measurements; distance; analysis; spatial genome ... See more keywords
The anti-cancer drugs curaxins target spatial genome organization
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09500-7
Abstract: Recently we characterized a class of anti-cancer agents (curaxins) that disturbs DNA/histone interactions within nucleosomes. Here, using a combination of genomic and in vitro approaches, we demonstrate that curaxins strongly affect spatial genome organization and… read more here.
Keywords: anti cancer; organization; genome organization; spatial genome ... See more keywords