Mechanism of Rotenone Toxicity against Plutella xylostella: New Perspective from a Spatial Metabolomics and Lipidomics Study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c06292
Abstract: The botanical pesticide rotenone can effectively control target pest Plutella xylostella, yet insights into in situ metabolic regulation of P. xylostella toward rotenone remain limited. Herein, we demonstrated metabolic expression levels and spatial distribution of… read more here.
Keywords: rotenone; toxicity; plutella xylostella; metabolomics lipidomics ... See more keywords
Applying Spatial Metabolomics To Investigate Age- and Drug-Induced Neurochemical Changes
Sign Up to like & getrecommendations! Published in 2024 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.4c00199
Abstract: In an era when population aging is increasing the burden of neurodegenerative conditions, deciphering the mechanisms underlying brain senescence is more important than ever. Here, we present a spatial metabolomics analysis of age-induced neurochemical alterations… read more here.
Keywords: induced neurochemical; age; applying spatial; age dependent ... See more keywords
From microbes to molecules: unveiling host-microbe interactions with spatial metabolomics
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Systems Biology"
DOI: 10.1038/s44320-025-00129-x
Abstract: Spatial metabolomics is transforming our understanding of microbial systems by uncovering the localized molecular dynamics within complex microbial communities. By using advanced mass spectrometry imaging techniques, researchers can now visualize metabolites at the micron scale… read more here.
Keywords: microbe interactions; microbial communities; spatial metabolomics; host microbe ... See more keywords
Can spatially resolved metabolomics uncover weak points in tumors?
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Proteomics"
DOI: 10.1080/14789450.2023.2176754
Abstract: The complexity and diversity derived from genetics and evolution lead to tumor heterogeneity. The spatial and temporal evolution of tumor heterogeneity during tumor development results in the dynamic reprogramming of the tumor microenvironment (TME) [1].… read more here.
Keywords: heterogeneity; mass spectrometry; spatially resolved; spatial metabolomics ... See more keywords
Spatial metabolomics and its application in the liver.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000341
Abstract: Hepatocytes work in highly structured, repetitive hepatic lobules. Blood flow across the radial axis of the lobule generates oxygen, nutrient, and hormone gradients that result in zoned spatial variability and functional diversity. This large heterogeneity… read more here.
Keywords: heterogeneity; metabolomics application; liver spatial; application liver ... See more keywords
Spatial metabolomics for symbiotic marine invertebrates
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.1101/2022.10.05.511040
Abstract: Microbial symbionts frequently localize within specific body structures or cell types of their multicellular hosts. This spatiotemporal niche is critical to host health, nutrient exchange and fitness. Measuring host-microbe metabolite exchange has conventionally relied on… read more here.
Keywords: metabolomics symbiotic; marine invertebrates; spatial metabolomics; host ... See more keywords
Spatial metabolomics identifies localized chemical changes in heart tissue during chronic cardiac Chagas Disease
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0009819
Abstract: Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is one of nineteen neglected tropical diseases. CD is a vector-borne disease transmitted by triatomines, but CD can also be transmitted through blood transfusions, organ transplants,… read more here.
Keywords: spatial metabolomics; disease; cruzi; chagas disease ... See more keywords
Spatial metabolomics reveal mechanisms of dexamethasone against pediatric pneumonia.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.2139/ssrn.4369317
Abstract: Currently, drugs are limited to treating pediatric pneumonia in clinical practice. It is urgent to find one new precise prevention and control therapy. The dynamically changing biomarkers during the development of pediatric pneumonia could help… read more here.
Keywords: pneumonia; pediatric pneumonia; reveal mechanisms; metabolomics reveal ... See more keywords
When cancer drug resistance meets metabolomics (bulk, single-cell and/or spatial): Progress, potential, and perspective
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1054233
Abstract: Resistance to drug treatment is a critical barrier in cancer therapy. There is an unmet need to explore cancer hallmarks that can be targeted to overcome this resistance for therapeutic gain. Over time, metabolic reprogramming… read more here.
Keywords: cancer drug; spatial metabolomics; drug; cancer ... See more keywords