Mass Spectrometry Spatial-Omics on a Single Conductive Slide
Sign Up to like & getrecommendations! Published in 2021 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.0c04572
Abstract: Mass spectrometry imaging (MSI) can analyze the spatial distribution of hundreds of different molecules directly from tissue sections usually placed on conductive glass slides to provide conductivity on the sample surface. Additional experiments are often… read more here.
Keywords: spatial omics; single conductive; conductive slide; mass spectrometry ... See more keywords
ATHENA: analysis of tumor heterogeneity from spatial omics measurements
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac303
Abstract: Abstract Summary Tumor heterogeneity has emerged as a fundamental property of most human cancers, with broad implications for diagnosis and treatment. Recently, spatial omics have enabled spatial tumor profiling, however computational resources that exploit the… read more here.
Keywords: tumor heterogeneity; heterogeneity; analysis tumor; heterogeneity spatial ... See more keywords
Aquila: a spatial omics database and analysis platform
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac874
Abstract: Abstract Spatial omics is a rapidly evolving approach for exploring tissue microenvironment and cellular networks by integrating spatial knowledge with transcript or protein expression information. However, there is a lack of databases for users to… read more here.
Keywords: platform; database; analysis; spatial omics ... See more keywords
Single cell‐ and spatial ‘Omics revolutionize physiology
Sign Up to like & getrecommendations! Published in 2022 at "Acta Physiologica"
DOI: 10.1111/apha.13848
Abstract: Single cell multi‐ ‘Omics and Spatial Transcriptomics are prominent technological highlights of recent years, and both fields still witness a ceaseless firework of novel approaches for high resolution profiling of additional omics layers. As all… read more here.
Keywords: omics revolutionize; cell spatial; physiology; single cell ... See more keywords
Microbial Pathogenesis in the Era of Spatial Omics
Sign Up to like & getrecommendations! Published in 2023 at "Infection and Immunity"
DOI: 10.1128/iai.00442-22
Abstract: The biology of a cell, whether it is a unicellular organism or part of a multicellular network, is influenced by cell type, temporal changes in cell state, and the cell’s environment. Spatial cues play a… read more here.
Keywords: cell; pathogenesis era; spatial omics; microbial pathogenesis ... See more keywords
Abstract 4703: Applying spatial omics and computational integrative analyses to study drug responses and cancer immune cell interactions
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4703
Abstract: Cancer responses to drug treatment are highly heterogeneous. We postulate that spatial determinants in the tumour play a critical role in cancer therapy outcomes. Here, we will present two spatial transcriptomics studies on spatial responses… read more here.
Keywords: cell; omics computational; spatial omics; drug ... See more keywords
Abstract 5639: High throughput spatially resolved laser-activated cell sorting links the genomic molecules with its spatial information
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5639
Abstract: Spatial omics profiling technologies have been recognized recently for its ability to decipher the genetic molecules that are structurally relevant in pathology. Especially, in tumor biology, tumor is not the group of malignant tumor cells,… read more here.
Keywords: information; cell; activated cell; spatial omics ... See more keywords
The promise and challenge of spatial omics in dissecting tumour microenvironment and the role of AI
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1172314
Abstract: Growing evidence supports the critical role of tumour microenvironment (TME) in tumour progression, metastases, and treatment response. However, the in-situ interplay among various TME components, particularly between immune and tumour cells, are largely unknown, hindering… read more here.
Keywords: tumour microenvironment; cell; role; promise challenge ... See more keywords
Application of Single-Cell and Spatial Omics in Musculoskeletal Disorder Research
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032271
Abstract: Musculoskeletal disorders, including fractures, scoliosis, heterotopic ossification, osteoporosis, osteoarthritis, disc degeneration, and muscular injury, etc., can occur at any stage of human life. Understanding the occurrence and development mechanism of musculoskeletal disorders, as well as… read more here.
Keywords: cell; cell spatial; single cell; spatial omics ... See more keywords