Mass Spectrometry Spatial-Omics on a Single Conductive Slide
Sign Up to like & getrecommendations! Published in 2021 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.0c04572
Abstract: Mass spectrometry imaging (MSI) can analyze the spatial distribution of hundreds of different molecules directly from tissue sections usually placed on conductive glass slides to provide conductivity on the sample surface. Additional experiments are often… read more here.
Keywords: spatial omics; single conductive; conductive slide; mass spectrometry ... See more keywords
Advancements in Nanomaterials and Molecular Probes for Spatial Omics.
Sign Up to like & getrecommendations! Published in 2025 at "ACS nano"
DOI: 10.1021/acsnano.4c18470
Abstract: Spatial omics is emerging as a focus of life sciences because of its applications in investigating the molecular mechanisms of cancer, mapping cellular distributions, and revealing specific cellular ecological niches. Notably, the in-depth acquisition of… read more here.
Keywords: advancements nanomaterials; spatial omics; molecular probes; nanomaterials molecular ... See more keywords
MENDER: fast and scalable tissue structure identification in spatial omics data
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-023-44367-9
Abstract: Tissue structure identification is a crucial task in spatial omics data analysis, for which increasingly complex models, such as Graph Neural Networks and Bayesian networks, are employed. However, whether increased model complexity can effectively lead… read more here.
Keywords: tissue structure; structure identification; identification; spatial omics ... See more keywords
BANKSY unifies cell typing and tissue domain segmentation for scalable spatial omics data analysis
Sign Up to like & getrecommendations! Published in 2024 at "Nature Genetics"
DOI: 10.1038/s41588-024-01664-3
Abstract: Spatial omics data are clustered to define both cell types and tissue domains. We present Building Aggregates with a Neighborhood Kernel and Spatial Yardstick (BANKSY), an algorithm that unifies these two spatial clustering problems by… read more here.
Keywords: banksy; domain segmentation; spatial omics; cell typing ... See more keywords
ATHENA: analysis of tumor heterogeneity from spatial omics measurements
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac303
Abstract: Abstract Summary Tumor heterogeneity has emerged as a fundamental property of most human cancers, with broad implications for diagnosis and treatment. Recently, spatial omics have enabled spatial tumor profiling, however computational resources that exploit the… read more here.
Keywords: tumor heterogeneity; heterogeneity; analysis tumor; heterogeneity spatial ... See more keywords
Emerging AI approaches for cancer spatial omics
Sign Up to like & getrecommendations! Published in 2025 at "GigaScience"
DOI: 10.1093/gigascience/giaf128
Abstract: Abstract Technological breakthroughs in spatial omics and artificial intelligence (AI) have the potential to transform the understanding of cancer cells and the tumor microenvironment. Here we review the role of AI in spatial omics, discussing… read more here.
Keywords: approaches cancer; cancer; spatial omics; cancer spatial ... See more keywords
Aquila: a spatial omics database and analysis platform
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac874
Abstract: Abstract Spatial omics is a rapidly evolving approach for exploring tissue microenvironment and cellular networks by integrating spatial knowledge with transcript or protein expression information. However, there is a lack of databases for users to… read more here.
Keywords: platform; database; analysis; spatial omics ... See more keywords
Digital pathology and spatial omics in steatohepatitis: Clinical applications and discovery potentials.
Sign Up to like & getrecommendations! Published in 2024 at "Hepatology"
DOI: 10.1097/hep.0000000000000866
Abstract: Steatohepatitis with diverse etiologies is the most common histological manifestation in patients with liver disease. However, there are currently no specific histopathological features pathognomonic for metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD),… read more here.
Keywords: spatial omics; pathology spatial; digital pathology; pathology ... See more keywords
On metrics for subpopulation detection in single-cell and spatial omics data
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1101/2024.11.28.625845
Abstract: Benchmarks are crucial to understanding the strengths and weaknesses of the growing number of tools for single-cell and spatial omics analysis. A key task is to distinguish subpopulations within complex tissues, where evaluation typically relies… read more here.
Keywords: detection; single cell; spatial omics; cell ... See more keywords
Single cell‐ and spatial ‘Omics revolutionize physiology
Sign Up to like & getrecommendations! Published in 2022 at "Acta Physiologica"
DOI: 10.1111/apha.13848
Abstract: Single cell multi‐ ‘Omics and Spatial Transcriptomics are prominent technological highlights of recent years, and both fields still witness a ceaseless firework of novel approaches for high resolution profiling of additional omics layers. As all… read more here.
Keywords: omics revolutionize; cell spatial; physiology; single cell ... See more keywords
Microbial Pathogenesis in the Era of Spatial Omics
Sign Up to like & getrecommendations! Published in 2023 at "Infection and Immunity"
DOI: 10.1128/iai.00442-22
Abstract: The biology of a cell, whether it is a unicellular organism or part of a multicellular network, is influenced by cell type, temporal changes in cell state, and the cell’s environment. Spatial cues play a… read more here.
Keywords: cell; pathogenesis era; spatial omics; microbial pathogenesis ... See more keywords