Spatial organization of the Schizosaccharomyces pombe genome within the nucleus
Sign Up to like & getrecommendations! Published in 2017 at "Yeast"
DOI: 10.1002/yea.3217
Abstract: The fission yeast Schizosaccharomyces pombe is a useful experimental system for studying the organization of chromosomes within the cell nucleus. S. pombe has a small genome that is organized into three chromosomes. The small size… read more here.
Keywords: spatial organization; microscopy; schizosaccharomyces pombe; pombe genome ... See more keywords
An Algorithm for the Analysis of the 3D Spatial Organization of the Genome.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0664-3_17
Abstract: We present an algorithm, and its MATLAB implementation, based on mathematical methods to detect and localize 3D multicolor DNA FISH spots in fluorescence cell image z-stacks. This algorithm provides a method to measure the relative… read more here.
Keywords: spatial organization; algorithm analysis; organization genome;
MYO6 Regulates Spatial Organization of Signaling Endosomes Driving AKT Activation and Actin Dynamics
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.05.048
Abstract: Summary APPL1- and RAB5-positive signaling endosomes play a crucial role in the activation of AKT in response to extracellular stimuli. Myosin VI (MYO6) and two of its cargo adaptor proteins, GIPC and TOM1/TOM1L2, localize to… read more here.
Keywords: spatial organization; activation; myo6 regulates; signaling endosomes ... See more keywords
Fraternal Polyandry and Clannish Spatial Organization in a Flightless Island Bird
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2018.03.059
Abstract: Polyandry has been studied in many species, especially birds [1]. Exclusively fraternal polyandry (several full or half-brothers with one unrelated female) is only known in human societies [2, 3], in which it is an important… read more here.
Keywords: spatial organization; polyandry clannish; fraternal polyandry; clannish spatial ... See more keywords
The spatial organization of cGAS-TREX1 interactions.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.03.016
Abstract: Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms to avoid autoimmunity. A key factor is the exonuclease TREX1, which antagonizes DNA-mediated activation of cGAS. Two studies, by Mohr et al. (2021)… read more here.
Keywords: spatial organization; cgas; trex1; trex1 interactions ... See more keywords
Spatial Organization of Single mRNPs at Different Stages of the Gene Expression Pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.10.010
Abstract: mRNAs form ribonucleoprotein complexes (mRNPs) by association with proteins that are crucial for mRNA metabolism. While the mRNP proteome has been well characterized, little is known about mRNP organization. Using a single-molecule approach, we show that mRNA conformation… read more here.
Keywords: spatial organization; organization single; mrnps different; mrnps ... See more keywords
Mechanical properties of glassy polymers with controlled NP spatial organization
Sign Up to like & getrecommendations! Published in 2020 at "Polymer Testing"
DOI: 10.1016/j.polymertesting.2020.106640
Abstract: Abstract Industrially viable processes enabling effective control of nanoparticle (NP) spatial organization in polymers are vitally important for achieving potential of nano-composites as building blocks of dynamic composites. Here, we report on the small and… read more here.
Keywords: spatial organization; glassy polymers; properties glassy; polymer ... See more keywords
On the spatial organization of hairpin packets in a turbulent boundary layer at low-to-moderate Reynolds number
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Fluid Mechanics"
DOI: 10.1017/jfm.2018.160
Abstract: The present study is devoted to characterizing the coherent organization of vortical structures, which can be fitted into the paradigm of the hairpin-packet model, in the streamwise–wall-normal plane of a canonical turbulent boundary layer at… read more here.
Keywords: spatial organization; boundary layer; turbulent boundary; hairpin packets ... See more keywords
Reconstruction of cell spatial organization from single-cell RNA sequencing data based on ligand-receptor mediated self-assembly
Sign Up to like & getrecommendations! Published in 2020 at "Cell Research"
DOI: 10.1038/s41422-020-0353-2
Abstract: Single-cell RNA sequencing (scRNA-seq) has revolutionized transcriptomic studies by providing unprecedented cellular and molecular throughputs, but spatial information of individual cells is lost during tissue dissociation. While imaging-based technologies such as in situ sequencing show… read more here.
Keywords: spatial organization; single cell; cell rna; rna sequencing ... See more keywords
Spatial organization of transcribed eukaryotic genes.
Sign Up to like & getrecommendations! Published in 2022 at "Nature cell biology"
DOI: 10.1038/s41556-022-00847-6
Abstract: Despite the well-established role of nuclear organization in the regulation of gene expression, little is known about the reverse: how transcription shapes the spatial organization of the genome. Owing to the small sizes of most… read more here.
Keywords: transcribed eukaryotic; transcription loops; organization transcribed; organization ... See more keywords
Polymer architecture orchestrates the segregation and spatial organization of replicating E. coli chromosomes in slow growth.
Sign Up to like & getrecommendations! Published in 2022 at "Soft matter"
DOI: 10.1039/d2sm00734g
Abstract: The mechanism of chromosome segregation and organization in the bacterial cell cycle of E. coli is one of the least understood aspects in its life cycle. The E. coli chromosome is often modelled as a… read more here.
Keywords: polymer; architecture orchestrates; polymer architecture; chromosome ... See more keywords