Abstract 5647: Single cell, multiomic spatial phenotyping of immunotherapy responses in head and neck cancer
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DOI: 10.1158/1538-7445.am2023-5647
Abstract: Background: Immune checkpoint inhibitors (ICI) have proven to be game-changing treatments for mucosal head and neck squamous cell cancer (HNSCC). Emerging successes with anti-PD-1/PD-L1 therapy have led to durable responses and prolonged survival in both… read more here.
Keywords: cell; biology; multiomic spatial; single cell ... See more keywords
Abstract 6768: The potential predictive role of spatial phenotyping in non-small cell lung cancer
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DOI: 10.1158/1538-7445.am2023-6768
Abstract: Background Lung cancers are the leading cause of cancer-related deaths with a 5-year-survival of only ~20%. Whilst immunotherapies have led to durable and prolonged survival, only a subset of patients remain responsive. Additional biomarkers are… read more here.
Keywords: cell; non small; lung; small cell ... See more keywords
Abstract 3651: Mutational analysis and spatial phenotyping to decipher racial disparities in pancreatic adenocarcinoma
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DOI: 10.1158/1538-7445.am2024-3651
Abstract: Background: Pancreatic cancer has a 5-year survival of only 12%. This is due to the lack of effective treatments and virtually no early detection methods. To compound this already poor prognosis, African Americans face a… read more here.
Keywords: cancer; african american; analysis; biology ... See more keywords
Abstract 5504: Integrating ultrahigh-plex spatial phenotyping: From discovery to clinical applications
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DOI: 10.1158/1538-7445.am2024-5504
Abstract: Background The journey from discovering predictive spatial biomarkers (known as spatial signatures) for immunotherapy responses to their clinical application necessitates a cohesive approach bridging ultrahigh-plex discovery experiments with high-throughput translational studies. This study focuses on… read more here.
Keywords: ultrahigh plex; discovery clinical; analysis; spatial phenotyping ... See more keywords
Spatial phenotyping of human bronchial airways in obstructive lung disease
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DOI: 10.1186/s12931-025-03315-5
Abstract: Chronic respiratory diseases such as asthma and COPD involve interactions between multiple resident and immune cell types within bronchial airways, resulting in structural and functional changes. Thus cellular heterogeneity, arrangements and associated neighborhoods as well… read more here.
Keywords: non asthmatics; disease; copd; cell ... See more keywords