Spatial and Single‐Cell Transcriptomics Unraveled Spatial Evolution of Papillary Thyroid Cancer
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DOI: 10.1002/advs.202404491
Abstract: Recurrence and metastasis are the major issues for papillary thyroid cancer (PTC). Current morphological and molecular classification systems are not satisfied for PTC diagnosis due to lacking variant‐specific morphological criteria and high signal‐to‐noise in mutation‐based… read more here.
Keywords: evolution; single cell; spatial single; thyroid cancer ... See more keywords
Identification of a Novel ECM Remodeling Macrophage Subset in AKI to CKD Transition by Integrative Spatial and Single‐Cell Analysis (Adv. Sci. 38/2024)
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DOI: 10.1002/advs.202470228
Abstract: Spatial Transcriptomic The cover depicts a Chinese Taoist concept: Yang promotes tissue repair through dynamic equilibrium, while imbalance of Yin disrupts tissue's ability to regenerate, leading to fibrosis. In article number 2309752, Yi‐Lin Zhang, Lin‐Li… read more here.
Keywords: ckd transition; spatial single; single cell; aki ckd ... See more keywords
Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
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DOI: 10.1158/0008-5472.can-24-1509
Abstract: Tumor cells in different intratumoral neighborhoods display divergent patterns of ligands that regulate γδT-cell activation, highlighting multilevel regulation of antitumor immunity resulting from the heterogeneity of intercellular interactions in the tumor microenvironment. read more here.
Keywords: analyses reveal; single cell; spatial single; cell analyses ... See more keywords
Abstract 7156: Spatial single-cell transcriptomics identifies tumor niches predictive of response to TKI therapy in non-small cell lung cancer
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DOI: 10.1158/1538-7445.am2025-7156
Abstract: Non-small cell lung cancer (NSCLC) is the tumor with the highest mortality in the world. Tyrosine kinase inhibitors (TKI) are commonly used treatment options for NSCLC, albeit with significantly different mechanisms of action. Responses to… read more here.
Keywords: cancer; lung cancer; spatial single; cell ... See more keywords
Abstract B069: Spatial and single-cell proteomic landscaping of the hypoxic microenvironment in glioblastoma
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DOI: 10.1158/1557-3265.liqbiop24-b069
Abstract: Glioblastoma (GBM) is a fatal adult solid tumour with median overall survival of 18-20 months post-diagnosis; contributing factors to therapeutic inefficacy include acquisition of genomic alterations post-therapy, immune evasion, deregulated hypervascularization, and tumor microenvironmental factors… read more here.
Keywords: hypoxic microenvironment; single cell; spatial single; cell proteomic ... See more keywords
Robust Variable Selection with Exponential Squared Loss for the Spatial Single-Index Varying-Coefficient Model
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DOI: 10.3390/e25020230
Abstract: As spatial correlation and heterogeneity often coincide in the data, we propose a spatial single-index varying-coefficient model. For the model, in this paper, a robust variable selection method based on spline estimation and exponential squared… read more here.
Keywords: spatial single; varying coefficient; single index; model ... See more keywords