Spatial transcriptome analysis reveals de novo regeneration of poplar roots
Sign Up to like & getrecommendations! Published in 2024 at "Horticulture Research"
DOI: 10.1093/hr/uhae237
Abstract: Abstract Propagation through cuttings is a well-established and effective technique for plant multiplication. This study explores the regeneration of poplar roots using spatial transcriptomics to map a detailed developmental trajectory. Mapping of the time-series transcriptome… read more here.
Keywords: spatial transcriptome; analysis; poplar roots; transcriptome analysis ... See more keywords
Submandibular gland tissue RNAseq and spatial transcriptome analyses in IgG4-related disease.
Sign Up to like & getrecommendations! Published in 2024 at "Rheumatology"
DOI: 10.1093/rheumatology/keae393
Abstract: OBJECTIVE To identify genes that could provide clues leading to the discovery of drugs to treat IgG4-related disease (IgG4-RD). METHODS Submandibular gland tissue bulk RNAseq analysis of 45 cases with a definite diagnosis of IgG4-RD… read more here.
Keywords: submandibular gland; gland tissue; igg4 related; related disease ... See more keywords
Discovering cancer stem‐like molecule, nuclear factor I X, using spatial transcriptome in gastric cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Science"
DOI: 10.1111/cas.16288
Abstract: Gastric cancer (GC) is characterized by significant intratumoral heterogeneity, and stem cells are promising therapeutic targets. Despite advancements in spatial transcriptome analyses, unexplored targets for addressing cancer stemness remain unknown. This study aimed to identify… read more here.
Keywords: cancer; spatial transcriptome; stem; gastric cancer ... See more keywords
Rack1‐mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights
Sign Up to like & getrecommendations! Published in 2024 at "Cell Proliferation"
DOI: 10.1111/cpr.13618
Abstract: Anorectal malformation (ARM), a common congenital anomaly of the digestive tract, is a result of insufficient elongation of the urorectal septum. The cytoplasmic protein Receptor of Activated C‐Kinase 1 (Rack1) is involved in embryonic neural… read more here.
Keywords: rack1; spatial transcriptome; hindgut development; development ... See more keywords
MVST: Identifying spatial domains of spatial transcriptomes from multiple views using multi-view graph convolutional networks
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1012409
Abstract: Spatial transcriptome technology can parse transcriptomic data at the spatial level to detect high-throughput gene expression and preserve information regarding the spatial structure of tissues. Identifying spatial domains, that is identifying regions with similarities in… read more here.
Keywords: spatial domains; information; graph convolutional; spatial transcriptome ... See more keywords
Resolving the gene expression maps of human first-trimester chorionic villi with spatial transcriptome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1060298
Abstract: The placenta is important for fetal development in mammals, and spatial transcriptomic profiling of placenta helps to resolve its structure and function. In this study, we described the landscape of spatial transcriptome of human placental… read more here.
Keywords: cell; first trimester; villi; spatial transcriptome ... See more keywords
Spatial Transcriptome Uncovers the Mouse Lung Architectures and Functions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.858808
Abstract: Diseases leading to lung structural and functional disruption pose a major threat to human health (Tobin, 2005; Nathan et al., 2019; Podolanczuk et al., 2021). Mouse models represent a common choice to investigate physiological and… read more here.
Keywords: scrna seq; transcriptome uncovers; mouse lung; lung ... See more keywords
Discovering hematoma-stimulated circuits for secondary brain injury after intraventricular hemorrhage by spatial transcriptome analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1123652
Abstract: Central nervous system (CNS) diseases, such as neurodegenerative disorders and brain diseases caused by acute injuries, are important yet challenging to study due to disease leisions’ locations and other complexities. Utilizing the powerful spatial transcriptome… read more here.
Keywords: transcriptome analysis; brain; analysis; spatial transcriptome ... See more keywords
CVAM: CNA Profile Inference of the Spatial Transcriptome Based on the VGAE and HMM
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13050767
Abstract: Tumors are often polyclonal due to copy number alteration (CNA) events. Through the CNA profile, we can understand the tumor heterogeneity and consistency. CNA information is usually obtained through DNA sequencing. However, many existing studies… read more here.
Keywords: information; transcriptome; cna events; spatial transcriptome ... See more keywords
Identification of invasive subpopulations using spatial transcriptome analysis in thyroid follicular tumors
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Pathology and Translational Medicine"
DOI: 10.4132/jptm.2023.11.21
Abstract: Background Follicular tumors include follicular thyroid adenomas and carcinomas; however, it is difficult to distinguish between the two when the cytology or biopsy material is obtained from a portion of the tumor. The presence or… read more here.
Keywords: spatial transcriptome; follicular thyroid; follicular tumors; thyroid carcinomas ... See more keywords