Resolving the gene expression maps of human first-trimester chorionic villi with spatial transcriptome
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DOI: 10.3389/fcell.2022.1060298
Abstract: The placenta is important for fetal development in mammals, and spatial transcriptomic profiling of placenta helps to resolve its structure and function. In this study, we described the landscape of spatial transcriptome of human placental… read more here.
Keywords: cell; first trimester; villi; spatial transcriptome ... See more keywords
Spatial Transcriptome Uncovers the Mouse Lung Architectures and Functions
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DOI: 10.3389/fgene.2022.858808
Abstract: Diseases leading to lung structural and functional disruption pose a major threat to human health (Tobin, 2005; Nathan et al., 2019; Podolanczuk et al., 2021). Mouse models represent a common choice to investigate physiological and… read more here.
Keywords: scrna seq; transcriptome uncovers; mouse lung; lung ... See more keywords
Discovering hematoma-stimulated circuits for secondary brain injury after intraventricular hemorrhage by spatial transcriptome analysis
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DOI: 10.3389/fimmu.2023.1123652
Abstract: Central nervous system (CNS) diseases, such as neurodegenerative disorders and brain diseases caused by acute injuries, are important yet challenging to study due to disease leisions’ locations and other complexities. Utilizing the powerful spatial transcriptome… read more here.
Keywords: transcriptome analysis; brain; analysis; spatial transcriptome ... See more keywords
CVAM: CNA Profile Inference of the Spatial Transcriptome Based on the VGAE and HMM
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DOI: 10.3390/biom13050767
Abstract: Tumors are often polyclonal due to copy number alteration (CNA) events. Through the CNA profile, we can understand the tumor heterogeneity and consistency. CNA information is usually obtained through DNA sequencing. However, many existing studies… read more here.
Keywords: information; transcriptome; cna events; spatial transcriptome ... See more keywords