Spatial transcriptomic profiling to identify mesoderm progenitors with precision genomic screening and functional confirmation
Sign Up to like & getrecommendations! Published in 2022 at "Cell Proliferation"
DOI: 10.1111/cpr.13298
Abstract: Mesoderm, derived from a new layer between epiblast and hypoblast during gastrulation, can differentiate into various tissues, including muscles, bones, kidneys, blood, and the urogenital system. However, systematic elucidation of mesoderm characteristics and specific markers… read more here.
Keywords: mesoderm progenitors; identify mesoderm; progenitors precision; transcriptomic profiling ... See more keywords
Spatial and Transcriptomic Analysis of Perineural Invasion in Oral Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-4543
Abstract: Abstract Purpose: Perineural invasion (PNI), a common occurrence in oral squamous cell carcinomas, is associated with poor survival. Consequently, these tumors are treated aggressively. However, diagnostic criteria of PNI vary and its role as an… read more here.
Keywords: nerve tumor; analysis; spatial transcriptomic; cancer ... See more keywords
A Unified Probabilistic Framework for Modeling and Inferring Spatial Transcriptomic Data
Sign Up to like & getrecommendations! Published in 2023 at "Current Bioinformatics"
DOI: 10.2174/1574893618666230529145130
Abstract: Spatial transcriptomics (ST) can provide vital insights into tissue function with the spatial organization of cell types. However, most technologies have limited spatial resolution, i.e., each measured location contains a mixture of cells, which only… read more here.
Keywords: probabilistic framework; inferring spatial; unified probabilistic; modeling inferring ... See more keywords
Spatial transcriptomic profiling of coronary endothelial cells in SARS-CoV-2 myocarditis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1118024
Abstract: Objectives Our objective was to examine coronary endothelial and myocardial programming in patients with severe COVID-19 utilizing digital spatial transcriptomics. Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has well-established links to thrombotic and cardiovascular events.… read more here.
Keywords: coronary endothelial; endothelial cells; transcriptomic profiling; spatial transcriptomic ... See more keywords
Principles of Spatial Transcriptomics Analysis: A Practical Walk-Through in Kidney Tissue
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.809346
Abstract: Spatial transcriptomic technologies capture genome-wide readouts across biological tissue space. Moreover, recent advances in this technology, including Slide-seqV2, have achieved spatial transcriptomic data collection at a near-single cell resolution. To-date, a repertoire of computational tools… read more here.
Keywords: cell type; tissue; kidney tissue; spatial transcriptomic ... See more keywords
Deconvolution Tactics and Normalization in Renal Spatial Transcriptomics
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.812947
Abstract: The kidney is composed of heterogeneous groups of epithelial, endothelial, immune, and stromal cells, all in close anatomic proximity. Spatial transcriptomic technologies allow the interrogation of in situ expression signatures in health and disease, overlaid… read more here.
Keywords: cell; normalization renal; tactics normalization; deconvolution ... See more keywords