Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.10.032
Abstract: Stress granules (SGs) are cytoplasmic assemblies of proteins and non-translating mRNAs. Whereas much has been learned about SG formation, a major gap remains in understanding the compositional changes SGs undergo during normal disassembly and under… read more here.
Keywords: sumoylation; analysis stress; spatiotemporal proteomic; apex ... See more keywords
A cross-species spatiotemporal proteomic analysis identifies UBE3A-dependent signaling pathways and targets
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Psychiatry"
DOI: 10.1038/s41380-022-01484-z
Abstract: Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A. Restoring UBE3A levels is a potential disease-modifying therapy for AS and has recently entered clinical trials. There is… read more here.
Keywords: analysis; spatiotemporal proteomic; species spatiotemporal; analysis identifies ... See more keywords