Targeting Oncoproteins with a Positive Selection Assay for Protein Degraders
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DOI: 10.1182/blood-2020-141558
Abstract: Cancer genome sequencing studies have identified frequent driver mutations that alter the function of transcription factors (TFs). However, most TFs, are classically "undruggable". The discovery that IMiDs [immunomodulatory drugs e.g.Lenalidomide (LEN) and Pomalidomide (POM)] exert… read more here.
Keywords: dck ikzf1; pom; dck; spautin ... See more keywords