Modulation of Specialized Metabolite Production in Genetically Engineered Streptomyces pactum.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00718
Abstract: Filamentous soil bacteria are known to produce diverse specialized metabolites. Despite having enormous potential as a source of pharmaceuticals, they often produce bioactive metabolites at low titers. Here, we show that inactivation of the pactamycin,… read more here.
Keywords: production; conglobatin; modulation specialized; metabolite production ... See more keywords
Convergent biosynthetic transformations to a bacterial specialized metabolite
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemical Biology"
DOI: 10.1038/s41589-019-0331-5
Abstract: Microbes produce specialized metabolites to thrive in their natural habitats. However, it is rare that a given specialized metabolite is biosynthesized via pathways with distinct intermediates and enzymes. Here, we show that the core assembly… read more here.
Keywords: convergent biosynthetic; gram; biosynthetic transformations; transformations bacterial ... See more keywords
Is specialized metabolite regulation specialized?
Sign Up to like & getrecommendations! Published in 2023 at "Journal of experimental botany"
DOI: 10.1093/jxb/erad209
Abstract: Recent technical and theoretical advances have generated an explosion in the identification of specialized metabolite pathways. In comparison, our understanding of how these pathways are regulated is relatively lagging. This and specialized metabolite pathways relatively… read more here.
Keywords: botany; specialized metabolite; regulation specialized; metabolite regulation ... See more keywords
Assessing Specialized Metabolite Diversity in the Cosmopolitan Plant Genus Euphorbia L.
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2019.00846
Abstract: Coevolutionary theory suggests that an arms race between plants and herbivores yields increased plant specialized metabolite diversity and the geographic mosaic theory of coevolution predicts that coevolutionary interactions vary across geographic scales. Consequently, plant specialized… read more here.
Keywords: plant; diversity; plant genus; cosmopolitan plant ... See more keywords
Comparative Genomics among Closely Related Streptomyces Strains Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity
Sign Up to like & getrecommendations! Published in 2018 at "Antibiotics"
DOI: 10.3390/antibiotics7040086
Abstract: Specialized metabolites are of great interest due to their possible industrial and clinical applications. The increasing number of antimicrobial resistant infectious agents is a major health threat and therefore, the discovery of chemical diversity and… read more here.
Keywords: biosynthetic gene; diversity; specialized metabolite; gene clusters ... See more keywords
Developmental Stage- and Genotype-Dependent Regulation of Specialized Metabolite Accumulation in Fruit Tissues of Different Citrus Varieties
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20051245
Abstract: Flavor traits in citrus are the result of a blend of low molecular weight metabolites including sugars, acids, flavonoids and limonoids, these latter being mainly responsible for the characteristic bitter flavor in citrus. In this… read more here.
Keywords: accumulation; developmental stage; flavor; specialized metabolite ... See more keywords
MYC2: A Master Switch for Plant Physiological Processes and Specialized Metabolite Synthesis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043511
Abstract: The jasmonic acid (JA) signaling pathway plays important roles in plant defenses, development, and the synthesis of specialized metabolites synthesis. Transcription factor MYC2 is a major regulator of the JA signaling pathway and is involved… read more here.
Keywords: plant physiological; myc2; specialized metabolite; synthesis ... See more keywords