The Evolving Role of Specialized Pro-resolving Mediators in Modulating Neuroinflammation in Perioperative Neurocognitive Disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-21735-8_4
Abstract: Surgery can be a life-saving procedure; however, significant complications may occur after routine procedures especially in older and more frail patients. Perioperative neurocognitive disorders (PNDs), including delirium and postoperative cognitive dysfunction, are the most common… read more here.
Keywords: specialized pro; perioperative neurocognitive; pro resolving; role ... See more keywords
Specialized Pro-resolving Mediators Directs Cardiac Healing and Repair with Activation of Inflammation and Resolution Program in Heart Failure.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-21735-8_6
Abstract: After myocardial infarction, splenic leukocytes direct biosynthesis of specialized pro-resolving mediators (SPMs) that are essential for the resolution of inflammation and tissue repair. In a laboratory environment, after coronary ligation of healthy risk free rodents… read more here.
Keywords: specialized pro; repair; inflammation; heart failure ... See more keywords
Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108247
Abstract: SUMMARY Underlying mechanisms of how infectious inflammation is resolved by the host are incompletely understood. One hallmark of inflammation resolution is the activation of specialized pro-resolving mediators (SPMs) that enhance bacterial clearance and promote tissue… read more here.
Keywords: specialized pro; resolution; pro resolving; inflammation resolution ... See more keywords
Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.07.024
Abstract: Background Termination of acute inflammation is an active process orchestrated by lipid mediators (LM) derived from polyunsaturated fatty acids, referred to as specialized pro-resolving mediators (SPM). These mediators also provide novel therapeutic opportunities for treating… read more here.
Keywords: specialized pro; pro resolving; lipid mediators; myocardial infarction ... See more keywords
Specialized pro-resolving mediators in cardiovascular diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2017.02.003
Abstract: The resolution of inflammation is a highly regulated process enacted by endogenous mediators including specialized pro-resolving lipid mediators (SPMs): the lipoxins, resolvins, protectins and maresins. SPMs activate specific cellular receptors to temper the production of… read more here.
Keywords: specialized pro; resolving mediators; pro resolving; inflammation ... See more keywords
Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105556
Abstract: The pentacyclic triterpenoid quinone methide celastrol (CS) from Tripterygium wilfordii Hook. F. effectively ameliorates inflammation with potential as therapeutics for inflammatory diseases. However, the molecular mechanisms underlying the anti-inflammatory and inflammation-resolving features of CS are… read more here.
Keywords: anti inflammatory; specialized pro; lipid mediators; pro resolving ... See more keywords
Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-36679-4
Abstract: Specialized pro-resolving mediator(s) (SPMs) are produced from the endogenous ω-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and accelerate resolution of acute inflammation. We identified specific clusters of SPM in human… read more here.
Keywords: specialized pro; supplementation; mediator; endotoxin ... See more keywords
Specialized pro-resolving mediators in diabetes: novel therapeutic strategies.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical science"
DOI: 10.1042/cs20190067
Abstract: Diabetes mellitus (DM) is an important metabolic disorder characterized by persistent hyperglycemia resulting from inadequate production and secretion of insulin, impaired insulin action, or a combination of both. Genetic disorders and insulin receptor disorders, environmental… read more here.
Keywords: specialized pro; mediators diabetes; resolving mediators; pro resolving ... See more keywords
Staphylococcus aureus controls eicosanoid and specialized pro‐resolving mediator production via lipoteichoic acid
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13449
Abstract: Staphylococcus aureus causes severe infections associated with inflammation, such as sepsis or osteomyelitis. Inflammatory processes are regulated by distinct lipid mediators (LMs) but how their biosynthetic pathways are orchestrated in S. aureus infections is elusive.… read more here.
Keywords: pro resolving; specialized pro; staphylococcus aureus; aureus ... See more keywords
Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-051921-084047
Abstract: Specialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins, are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty acids during the acute phase or resolution phase of inflammation. Synthetic SPMs possess broad safety… read more here.
Keywords: toxicology; pharmacology; pro resolving; specialized pro ... See more keywords
Specialized pro-resolution mediators in the bladder: Receptor expression and recovery of bladder function from cystitis
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702211067465
Abstract: Inflammation is a central process in most benign bladder disorders, and its control is a delicate balance between initiating factors and resolving factors. While recent discoveries have shown a central role for the NLRP3 inflammasome… read more here.
Keywords: expression; specialized pro; bladder; pro resolution ... See more keywords