Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2131484
Abstract: Abstract Acyl glucuronides (AGs) are known as one of the causes of idiosyncratic drug toxicity (IDT). Although AGs can be enzymatically hydrolysed by β-glucuronidase and esterase, much information on their characteristics and species differences is… read more here.
Keywords: species differences; humans rats; acyl; hydrolysis ... See more keywords
Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir
Sign Up to like & getrecommendations! Published in 2023 at "Xenobiotica"
DOI: 10.1080/00498254.2023.2183158
Abstract: Abstract Plasma protein binding (PPB) studies on the SARS-CoV-2 main protease inhibitor nirmatrelvir revealed considerable species differences primarily in dog and rabbit, which prompted further investigations into the biochemical basis for these differences. The unbound… read more here.
Keywords: plasma protein; protein binding; species differences; cov main ... See more keywords
Individual differences exceed species differences in the movements of a river fish community
Sign Up to like & getrecommendations! Published in 2019 at "Behavioral Ecology"
DOI: 10.1093/beheco/arz076
Abstract: Repeatable individual differences often account for large proportions of intraspecific variation in animal movements. However, meta-population models have continued to rely on single species-level and season-specific species-level means for movement prediction. Here, we test the… read more here.
Keywords: community; movement; variation; ecology ... See more keywords
DNA methylation changes during preimplantation development reveal inter-species differences and reprogramming events at imprinted genes
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Epigenetics"
DOI: 10.1186/s13148-020-00857-x
Abstract: Preimplantation embryos experience profound resetting of epigenetic information inherited from the gametes. Genome-wide analysis at single-base resolution has shown similarities but also species differences between human and mouse preimplantation embryos in DNA methylation patterns and… read more here.
Keywords: methylation; species differences; imprinted genes; preimplantation embryos ... See more keywords
Species Differences in Platelet Protease-Activated Receptors
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098298
Abstract: Protease-activated receptors (PARs) are a class of integral membrane proteins that are cleaved by a variety of proteases, most notably thrombin, to reveal a tethered ligand and promote activation. PARs are critical mediators of platelet… read more here.
Keywords: species differences; protease activated; physiology; activated receptors ... See more keywords
Species Differences in Microsomal Metabolism of Xanthine-Derived A1 Adenosine Receptor Ligands
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14030277
Abstract: Tracer development for positron emission tomography (PET) requires thorough evaluation of pharmacokinetics, metabolism, and dosimetry of candidate radioligands in preclinical animal studies. Since variations in pharmacokinetics and metabolism of a compound occur in different species,… read more here.
Keywords: microsomal metabolism; species differences; metabolism; xanthine derived ... See more keywords