Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis.
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DOI: 10.1021/acs.jmedchem.1c01991
Abstract: Invasive fungal infections are emerging as serious infectious diseases worldwide. Because of the development of antifungal drug resistance, the limited efficacy of the existing drugs has led to high mortality in patients. The use of… read more here.
Keywords: species selective; hsp90; hsp90 design; selective targeting ... See more keywords
Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors.
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DOI: 10.1021/acs.jmedchem.2c00611
Abstract: With over 200 million cases and close to half a million deaths each year, malaria is a threat to global health, particularly in developing countries. Plasmodium falciparum, the parasite that causes the most severe form… read more here.
Keywords: design synthesis; macrocyclic peptides; species selective; proteasome inhibitors ... See more keywords