Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma
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DOI: 10.1038/s41598-024-56684-0
Abstract: Despite advancements in cancer immunotherapy, solid tumors remain formidable challenges. In glioma, profound inter- and intra-tumoral heterogeneity of antigen landscape hampers therapeutic development. Therefore, it is critical to consider alternative sources to expand the repertoire… read more here.
Keywords: alternative splicing; cell surface; specific alternative; surface antigens ... See more keywords
Cell-type-specific alternative splicing in the Arabidopsis germline
Sign Up to like & getrecommendations! Published in 2022 at "Plant Physiology"
DOI: 10.1093/plphys/kiac574
Abstract: Abstract During sexual reproduction in flowering plants, the two haploid sperm cells (SCs) embedded within the cytoplasm of a growing pollen tube are carried to the embryo sac for double fertilization. Pollen development in flowering… read more here.
Keywords: specific alternative; type specific; alternative splicing; arabidopsis ... See more keywords
Ontology Specific Alternative Splicing Changes in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.926049
Abstract: Alternative splicing (AS) is a common phenomenon and correlates with aging and aging-related disorders including Alzheimer’s disease (AD). We aimed to systematically characterize AS changes in the cerebral cortex of 9-month-old APP/PS1 mice. The GSE132177… read more here.
Keywords: specific alternative; alzheimer disease; ontology specific; ontology ... See more keywords
Integration of TE Induces Cancer Specific Alternative Splicing Events
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DOI: 10.3390/ijms231810918
Abstract: Alternative splicing of messenger RNA (mRNA) precursors contributes to genetic diversity by generating structurally and functionally distinct transcripts. In a disease state, alternative splicing promotes incidence and development of several cancer types through regulation of… read more here.
Keywords: splicing events; specific alternative; cancer specific; alternative splicing ... See more keywords