Antisense Oligonucleotides Selectively Enter Human-derived Antibiotic-Resistant Bacteria through bacterial-specific ATP-binding Cassette Sugar Transporter.
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DOI: 10.1002/adma.202300477
Abstract: Current vehicles used to deliver antisense oligonucleotides (ASOs) cannot distinguish between bacterial and mammalian cells, greatly hindering the preclinical or clinical treatment of bacterial infections, especially those caused by antibiotic-resistant bacteria. Herein, we leverage the… read more here.
Keywords: atp binding; antisense oligonucleotides; binding cassette; antibiotic resistant ... See more keywords