Nucleotide-Specific Autoinhibition of Full-Length K-Ras4B Identified by Extensive Conformational Sampling
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DOI: 10.3389/fmolb.2020.00145
Abstract: K-Ras is one of the most frequently mutated oncogenes in human tumor cells. It consists of a well-conserved globular catalytic domain and a flexible tail-like hypervariable region (HVR) at its C-terminal end. It plays a… read more here.
Keywords: gtp bound; bound state; gtp; specific autoinhibition ... See more keywords