Harnessing neoantigen specific CD4 T cells for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5ri0220-603rr
Abstract: The goal of precision immunotherapy is to direct a patient's T cell response against the immunogenic mutations expressed on their tumors. Most immunotherapy approaches to‐date have focused on MHC class I‐restricted peptide epitopes by which… read more here.
Keywords: cd4 cells; immunotherapy; cells cancer; cancer immunotherapy ... See more keywords
Superior B. pertussis Specific CD4+ T-Cell Immunity Imprinted by Natural Infection.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2019_405
Abstract: Pertussis remains endemic in vaccinated populations due to waning of vaccine-induced immunity and insufficient interruption of transmission. Correlates of long-term protection against whooping cough remain elusive but increasing evidence from experimental models indicates that the… read more here.
Keywords: immunity; infection; specific cd4; cd4 cell ... See more keywords
A novel dendritic cell-based direct ex vivo assay for detection and enumeration of circulating antigen-specific human T cells
Sign Up to like & getrecommendations! Published in 2018 at "Cytotechnology"
DOI: 10.1007/s10616-018-0222-8
Abstract: Although a variety of assays have been used to examine T cell responses in vitro, standardized ex vivo detection of antigen-specific CD4+ T cells from human circulatory PBMCs remains constrained by low-dimensional characterization outputs and… read more here.
Keywords: detection; circulating antigen; antigen specific; antigen ... See more keywords
HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47024-8
Abstract: The combined regulation of a network of inhibitory and activating T cell receptors may be a critical step in the development of chronic HCV infection. Ex vivo HCV MHC class I + II tetramer staining and bead-enrichment… read more here.
Keywords: cd4 cells; infection; hcv; hcv specific ... See more keywords
Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-86612-5
Abstract: Celiac disease is an auto-immune disease in which an immune response to dietary gluten leads to inflammation and subsequent atrophy of small intestinal villi, causing severe bowel discomfort and malabsorption of nutrients. The major instigating… read more here.
Keywords: disease; cell receptor; celiac disease; gluten specific ... See more keywords
Gag-Specific CD4 T Cell Proliferation, Plasmacytoid Dendritic Cells, and Ethnicity in Perinatally HIV-1-Infected Youths: The ANRS-EP38-IMMIP Study.
Sign Up to like & getrecommendations! Published in 2017 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2016.0177
Abstract: In perinatally HIV-1-infected youths living in France, we previously reported that Gag-specific CD4 and CD8 T cell proliferation is more frequently detected in patients of black ethnicity than in those of other ethnicities. We observed… read more here.
Keywords: gag specific; cell proliferation; specific cd4; cell ... See more keywords
Phenotypic Profile of Mycobacterium tuberculosis-Specific CD4 T-Cell Responses in People With Advanced Human Immunodeficiency Virus Who Develop Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac546
Abstract: Abstract Background Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a frequent complication of cotreatment for TB and human immunodeficiency virus (HIV)-1. We characterized Mycobacterium tuberculosis (Mtb)-specific CD4 T-cell phenotype and transcription factor profile associated with… read more here.
Keywords: mycobacterium tuberculosis; cd4; tuberculosis; cd4 cell ... See more keywords
THU0046 A PIPELINE TO STUDY ANTIGEN-SPECIFIC CD4+ T CELLS IN RHEUMATOID ARTHRITIS
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.1093
Abstract: Autoimmunity to citrullinated autoantigens forms a critical component of disease pathogenesis in rheumatoid arthritis (RA). Presence of anti-citrullinated protein antibodies (ACPAs) in patients has high diagnostic value. Recently, several citrullinated antigen specific CD4+T cells have… read more here.
Keywords: cd4 cells; cd4; specific cd4; antigen specific ... See more keywords
High-throughput Screening of Human Tumor Antigen–specific CD4 T Cells, Including Neoantigen-reactive T Cells
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-18-1356
Abstract: Purpose: Characterization of tumor antigen–specific CD4 T-cell responses in healthy donors and malignant melanoma patients using an in vitro amplified T-cell library screening procedure. Patients and Methods: A high-throughput, human leukocyte antigen (HLA)-independent approach was… read more here.
Keywords: cd4 cells; antigen; cd4; specific cd4 ... See more keywords
Abstract 5153: The role of CCL22-specific CD4 T cells in modulating the immunosuppressive tumor microenvironment in ovarian cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5153
Abstract: Background: CCL22, a macrophage-derived chemokine, is overexpressed in ovarian cancer and exerts immunosuppressive functions by the recruitment of regulatory T cells (Tregs) to the tumor microenvironment (TME). Our research group described naturally occurring T cells… read more here.
Keywords: ccl22 specific; ovarian cancer; ccl22; specific cd4 ... See more keywords
Human CD4+ T Cells Specific for Merkel Cell Polyomavirus Localize to Merkel Cell Carcinomas and Target a Required Oncogenic Domain
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-19-0103
Abstract: Tumor-specific CD4+ T-cell epitopes were identified and allowed detailed characterization of CD4+ T-cell responses in patients with Merkel cell carcinoma. The methods used in this study provide a foundation to investigate and develop CD4+ T… read more here.
Keywords: cd4 cells; merkel cell; cd4; specific cd4 ... See more keywords