Detection of Antigen-Specific CD8+ T Cells in the Livers of HCV Core Transgenic Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8976-8_31
Abstract: Hepatitis C virus-mediated immune suppression is an underlying feature leading to the establishment of viral persistence and chronic infection. In particular, HCV core protein has been shown to exhibit significant immunosuppressive activity of T cells… read more here.
Keywords: specific cd8; antigen specific; transgenic mice; core transgenic ... See more keywords
Immunological function of Langerhans cells in HIV infection.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2017.03.015
Abstract: BACKGROUND Langerhans cells (LCs) are one of the initial target cells for HIV following sexual exposure and they are productively infected by HIV. HIV-infected LCs migrate to the draining lymph nodes (dLNs) and transmit the… read more here.
Keywords: specific cd8; cd8 cells; hiv; hiv primed ... See more keywords
Defining Virus-specific CD8+ TCR Repertoires for Therapeutic Regeneration of T Cells against Chronic Hepatitis E.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2019.06.005
Abstract: BACKGROUND AND AIMS T-cell based therapy is a novel approach developed for cancer treatment, and recently in chronic infectious diseases. Potential target populations are immunosuppressed patients with chronic hepatitis E virus infection (cHEV) who are… read more here.
Keywords: specific cd8; hepatitis; hev; chronic hepatitis ... See more keywords
Activation and exhaustion of antigen-specific CD8+ T cells occur in different splenic compartments during infection with Plasmodium berghei.
Sign Up to like & getrecommendations! Published in 2017 at "Parasitology international"
DOI: 10.1016/j.parint.2017.01.022
Abstract: The spleen is the major organ in which T cells are primed during infection with malaria parasites. However, little is known regarding the dynamics of the immune responses and their localization within the splenic tissue… read more here.
Keywords: cd8 cells; specific cd8; infection; infection plasmodium ... See more keywords
Maintenance of the EBV-specific CD8+ TCRαβ repertoire in immunosuppressed lung transplant recipients
Sign Up to like & getrecommendations! Published in 2017 at "Immunology and Cell Biology"
DOI: 10.1038/icb.2016.71
Abstract: Epstein‐Barr virus (EBV) is one of the most common viruses in humans, capable of causing life‐threatening infections and cancers in immunocompromised individuals. Although CD8+ T cells provide key protection against EBV, the persistence and dynamics… read more here.
Keywords: tcr repertoire; specific cd8; tcr; transplant ... See more keywords
A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection
Sign Up to like & getrecommendations! Published in 2024 at "Nature"
DOI: 10.1038/s41586-024-07630-7
Abstract: Chronic hepatitis B virus (HBV) infection affects 300 million patients worldwide1,2, in whom virus-specific CD8 T cells by still ill-defined mechanisms lose their function and cannot eliminate HBV-infected hepatocytes3–7. Here we demonstrate that a liver immune… read more here.
Keywords: hbv; cd8 cells; cell; specific cd8 ... See more keywords
Development of a Molecular Adjuvant to Enhance Antigen-Specific CD8+ T Cell Responses
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33375-1
Abstract: Despite promising progress in malaria vaccine development, an efficacious subunit vaccine against P. falciparum remains to be licensed and deployed. This study aimed to improve on the immunogenicity of the leading liver-stage vaccine candidate (ChAd63-MVA… read more here.
Keywords: cd8 cell; specific cd8; cell responses; antigen specific ... See more keywords
Characteristics of Norovirus capsid protein-specific CD8+ T-Cell responses in previously infected individuals
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DOI: 10.1080/21505594.2024.2360133
Abstract: ABSTRACT Norovirus (NV) infection causes acute gastroenteritis in children and adults. Upon infection with NV, specific CD8+ T cells, which play an important role in anti-infective immunity, are activated in the host. Owing to the… read more here.
Keywords: cd8; infection; specific cd8; cell responses ... See more keywords
Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8+ T cells eradicates peritoneal metastases in mouse models
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2147317
Abstract: ABSTRACT Previous studies have shown that local delivery of tumor antigen-specific CD8+ T lymphocytes engineered to transiently express single-chain IL-12 mRNA is highly efficacious. Peritoneal dissemination of cancer is a frequent and often fatal patient… read more here.
Keywords: specific cd8; tumor; intracavitary adoptive; adoptive transfer ... See more keywords
Anti-CD122 antibody restores specific CD8+ T cell response in nonalcoholic steatohepatitis and prevents hepatocellular carcinoma growth
Sign Up to like & getrecommendations! Published in 2023 at "Oncoimmunology"
DOI: 10.1080/2162402x.2023.2184991
Abstract: ABSTRACT Nonalcoholic steatohepatitis (NASH) can lead to hepatocellular carcinoma (HCC). Although immunotherapy is used as first-line treatment for advanced HCC, the impact of NASH on anticancer immunity is only partially characterized. We assessed the tumor-specific… read more here.
Keywords: growth; cd122 antibody; specific cd8; anti cd122 ... See more keywords
T Regulatory Cell Induced Foxp3 Binds the IL2, IFNγ, and TNFα Promoters in Virus-Specific CD8+ T Cells from Feline Immunodeficiency Virus Infected Cats.
Sign Up to like & getrecommendations! Published in 2018 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2017.0187
Abstract: Polyfunctional CD8+ T cells play a critical role in controlling viremia during AIDS lentiviral infections. However, for most HIV-infected individuals, virus-specific CD8+ T cells exhibit loss of polyfunctionality, including loss of IL2, TNFα, and IFNγ.… read more here.
Keywords: specific cd8; tnf; cd8; cd8 cells ... See more keywords