Modular Antigen‐Specific T‐cell Biofactories for Calibrated In Vivo Synthesis of Engineered Proteins
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Biosystems"
DOI: 10.1002/adbi.201800210
Abstract: An artificial cell‐signaling pathway is developed that capitalizes on the T‐cell's innate extravasation ability and transforms it into a vector (T‐cell Biofactory) for synthesizing calibrated amounts of engineered proteins in vivo. The modularity of this… read more here.
Keywords: cell biofactory; specific cell; antigen specific; cell ... See more keywords
Diverse facets of MDSC in different phases of chronic HBV infection: Impact on HBV‐specific T‐cell response and homing
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32331
Abstract: Chronic HBV infection (CHI) is associated with a diverse natural history that includes immune‐tolerant (IT), HBeAg‐positive chronic hepatitis B (CHB) (EP‐CHB), inactive carrier, and HBeAg‐negative CHB (EN‐CHB) phases. A hallmark of CHI is impairment of… read more here.
Keywords: cell response; specific cell; hbv; hbv specific ... See more keywords
"Clickable" and Antifouling Block Copolymer Brushes as a Versatile Platform for Peptide-Specific Cell Attachment.
Sign Up to like & getrecommendations! Published in 2020 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201900354
Abstract: To tailor cell-surface interactions, precise and controlled attachment of cell-adhesive motifs is required, while any background non-specific cell and protein adhesion has to be blocked effectively. Herein, a versatile and highly reproducible antifouling surface modification… read more here.
Keywords: cell attachment; block; specific cell; cell ... See more keywords
Hapten-Specific T Cell-Mediated Skin Inflammation: Flow Cytometry Analysis of Mouse Skin Inflammatory Infiltrate.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6786-5_2
Abstract: Hapten-specific T cell-mediated skin inflammation also known as contact hypersensitivity (CHS) is characterized by a strong influx of CD8+ cytotoxic T cells within the skin upon reexposure of sensitized individuals to the same hapten. As… read more here.
Keywords: mediated skin; cell mediated; specific cell; hapten specific ... See more keywords
Isolation and Quantification Brain Region-Specific and Cell Subtype-Specific Histone (De)Acetylation in Cognitive Neuroepigenetics.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9434-2_16
Abstract: The acetylation of histone tails, which relaxes compact chromatin structure and enhances the accessibility of DNA to regulatory proteins, has emerged as a key mechanism for regulating gene expression. These modifications in turn play critical… read more here.
Keywords: histone acetylation; specific cell; brain; specific histone ... See more keywords
The effects of targeted immune-regulatory strategies on tumor-specific T-cell responses in vitro
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02760-z
Abstract: Immune-related adverse events (IrAEs) are auto-immune reactions associated with immune checkpoint inhibitor-based therapy (ICI). Steroids are currently the first-line option for irAE management; however, recent studies have raised concerns regarding their potential impairment of tumor-specific… read more here.
Keywords: targeted immune; specific cell; cell activation; tumor specific ... See more keywords
A PtdIns(3,4,5)P3 dispersal switch engages cell ratcheting at specific cell surfaces.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.08.016
Abstract: Force generation in epithelial tissues is often pulsatile, with actomyosin networks generating contractile forces before cyclically disassembling. This pulsed nature of cytoskeletal forces implies that there must be ratcheting mechanisms that drive processive transformations in… read more here.
Keywords: ptdins dispersal; cell surfaces; dispersal switch; specific cell ... See more keywords
Low mutational load in pediatric medulloblastoma still translates into neoantigens as targets for specific T-cell immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.06.009
Abstract: BACKGROUND Medulloblastoma is the most common malignant brain tumor in childhood and adolescence. Although some patients present with distinct genetic alterations, such as mutated TP53 or MYC amplification, pediatric medulloblastoma is a tumor entity with… read more here.
Keywords: mutational load; low mutational; medulloblastoma; specific cell ... See more keywords
Guidelines for analysis of low-frequency antigen-specific T cell results: Dye-based proliferation assay vs 3H-thymidine incorporation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2020.112907
Abstract: It is generally recognized that dysregulation of the immune system plays a critical role in many diseases, including autoimmune diseases and cancer. T cells play a crucial role in maintaining self-tolerance, while loss of immune… read more here.
Keywords: frequency; specific cell; antigen specific; proliferation ... See more keywords
CMV specific T cell immunity predicts early viremia after liver transplantation.
Sign Up to like & getrecommendations! Published in 2018 at "Transplant immunology"
DOI: 10.1016/j.trim.2018.09.004
Abstract: BACKGROUND Cytomegalovirus (CMV) infection is one of the most important factors affecting liver transplant with direct and indirect effects. However, CMV disease after transplant remains poorly predicted. OBJECTIVE In this study, preoperative CMV-specific cell-mediated immunity… read more here.
Keywords: cmv; immunity; specific cell; liver ... See more keywords
Multifunctional amyloid oligomeric nanoparticles for specific cell targeting and drug delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.0c01103
Abstract: Natural selection has endorsed proteins with amazing structures and functionalities that cannot be matched by synthetic means, explaining the exponential interest in developing protein-based materials. Protein self-assembly allows fabricating complex supramolecular structures from relatively simple… read more here.
Keywords: amyloid; delivery; specific cell; drug ... See more keywords