Association of Spike-Specific T Cells With Relative Protection From Subsequent SARS-CoV-2 Omicron Infection in Young Children
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Pediatrics"
DOI: 10.1001/jamapediatrics.2022.3868
Abstract: This cohort study investigates the risk of SARS-CoV-2 reinfection among young children with and without spike-specific T-cell responses. read more here.
Keywords: young children; specific cells; association spike; spike specific ... See more keywords
Programmed Death Ligand-1-Overexpressing Donor Exosomes Mediate Donor-Specific Immunosuppression by Delivering Co-inhibitory Signals to Donor-Specific T Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300670
Abstract: Programmed death ligand-1 (PD-L1) and donor antigens are critical for donor immature dendritic cells (DCs) targeting donor-specific T cells to induce transplant tolerance. This study aimed to clarify whether DC-derived exosomes (DEX) with donor antigens… read more here.
Keywords: inhibitory signals; specific cells; donor specific; donor ... See more keywords
Hematopoietic stem cell donor vaccination with cytomegalovirus triplex augments frequencies of functional and durable cytomegalovirus‐specific T cells in the recipient: A novel strategy to limit antiviral prophylaxis
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26824
Abstract: To enhance protective cytomegalovirus (CMV)‐specific T cells in immunosuppressed recipients of an allogeneic hematopoietic cell transplant (HCT), we evaluated post‐HCT impact of vaccinating healthy HCT donors with Triplex. Triplex is a viral vectored recombinant vaccine… read more here.
Keywords: cell; cmv specific; specific cells; hct ... See more keywords
CTLA‐4‐expression on VZV‐specific T cells in CSF and blood is specifically increased in patients with VZV related central nervous system infections
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747079
Abstract: VZV‐reactivation may lead to symptomatic central nervous system (CNS) diseases, but identification of VZV as causative pathogen of CNS‐diseases is challenging. This study was performed to characterize VZV‐specific T cells from cerebrospinal fluid (CSF) and… read more here.
Keywords: vzv; specific cells; csf blood; vzv related ... See more keywords
Malaria exposure drives both cognate and bystander human B cells to adopt an atypical phenotype
Sign Up to like & getrecommendations! Published in 2020 at "European journal of immunology"
DOI: 10.1002/eji.201948473
Abstract: Atypical memory B cells (aMBCs) are found in elevated numbers in individuals exposed to malaria. A key question is whether malaria induces aMBCs as a result of exposure to Ag, or non-Ag-specific mechanisms. We identified… read more here.
Keywords: malaria exposure; malaria; cells individuals; exposure ... See more keywords
Transglutaminase 2 affinity and enzyme‐substrate intermediate stability as determining factors for T‐cell responses to gluten peptides in celiac disease
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249862
Abstract: The adaptive immune response of celiac disease (CeD) involves presentation of gluten peptides to CD4+ T cells by transglutaminase 2 (TG2) specific B cells. This B‐cell/T‐cell crosstalk is facilitated by involvement of TG2:gluten peptide complexes… read more here.
Keywords: gluten peptides; celiac disease; specific cells; tg2 specific ... See more keywords
Generation of Antigen-Specific T Cells from Human Induced Pluripotent Stem Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8938-6_3
Abstract: Human induced pluripotent stem cells (iPSCs) are a potential source of blood cells for transfusion therapies and a promising tool for studying the ontogeny of hematopoiesis. The development of widely varying reprogramming methods has enabled… read more here.
Keywords: human induced; antigen specific; specific cells; stem ... See more keywords
Rapid Manufacture and Isolation of Highly Viable Interferon-γ Expressing Virus-Specific T Cells: Validation Results for the Virus-Specific Cytotoxic T-Lymphocyte Consortium for Refractory EBV, CMV, and Adenovirus Infections
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.589
Abstract: Background Children and young adults who develop treatment-refractory infection with EBV, CMV, and/or adenovirus (AdV) after allogeneic hematopoietic stem cell transplant (allo-HSCT) have a dismal prognosis (≥90% mortality). Adoptive transfer of ex-vivo expanded virus-specific cytotoxic… read more here.
Keywords: specific cytotoxic; cmv adenovirus; virus specific; specific cells ... See more keywords
Tracking down tumor-specific T cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer cell"
DOI: 10.1016/j.ccell.2022.03.007
Abstract: Two papers published in this edition of Cancer Cell (Zheng et al., 2022 and Veatch et al., 2022) provide an elegant illustration of how single-cell sequencing can be used to define a molecular phenotype which identifies tumor-specific… read more here.
Keywords: tumor specific; cell; tracking tumor; specific cells ... See more keywords
Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.108728
Abstract: Virus-specific humoral and cellular immunity act synergistically to protect the host from viral infection. We interrogate the dynamic changes of virological and immunological parameters in 12 patients with symptomatic acute SARS-CoV-2 infection from disease onset… read more here.
Keywords: disease; specific cells; sars cov; early induction ... See more keywords
Generation of high-affinity CMV-specific T cells for adoptive immunotherapy using IL-2, IL-15, and IL-21.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical immunology"
DOI: 10.1016/j.clim.2020.108456
Abstract: Cytomegalovirus (CMV) infection remains a life-threatening condition in individuals with a suppressed immune system. CMV may also represent a clinically relevant target for immune responses in CMV-positive malignancies. We established a protocol to expand CMV-specific… read more here.
Keywords: affinity cmv; cmv; high affinity; specific cells ... See more keywords