DeepCRISTL: deep transfer learning to predict CRISPR/Cas9 on-target editing efficiency in specific cellular contexts
Sign Up to like & getrecommendations! Published in 2024 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btae481
Abstract: Abstract Motivation CRISPR/Cas9 technology has been revolutionizing the field of gene editing. Guide RNAs (gRNAs) enable Cas9 proteins to target specific genomic loci for editing. However, editing efficiency varies between gRNAs and so computational methods… read more here.
Keywords: editing efficiency; high throughput; efficiency; deepcristl ... See more keywords
Rapid and structure-specific cellular uptake of selected steroids
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DOI: 10.1371/journal.pone.0224081
Abstract: Steroid hormones and their respective nuclear receptors are essential mediators in numerous physiologic and pathophysiologic processes, ranging from regulation of metabolism, immune function, and reproductive processes to the development of hormone-dependent cancers such as those… read more here.
Keywords: structure specific; rapid structure; specific cellular; structure ... See more keywords
Specific Cellular and Humoral Immune Responses to the Neoantigen RBD of SARS-CoV-2 in Patients with Primary and Secondary Immunodeficiency and Healthy Donors
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DOI: 10.3390/biomedicines11041042
Abstract: Patients with antibody deficiency disorders, such as primary immunodeficiency (PID) or secondary immunodeficiency (SID) to B-cell lymphoproliferative disorder (B-CLPD), are two groups vulnerable to developing the severe or chronic form of coronavirus disease caused by… read more here.
Keywords: sid patients; specific cellular; immunodeficiency; cellular responses ... See more keywords