Site-Specific Covalent Labeling of DNA Substrates by an RNA Transglycosylase
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DOI: 10.1021/jacs.3c00861
Abstract: Bacterial tRNA guanine transglycosylases (TGTs) catalyze the exchange of guanine for the 7-deazaguanine queuine precursor, prequeuosine1 (preQ1). While the native nucleic acid substrate for bacterial TGTs is the anticodon loop of queuine-cognate tRNAs, the minimum… read more here.
Keywords: specific covalent; dna; rna; dna substrates ... See more keywords
Site-specific covalent metalation of DNA oligonucleotides with phosphorescent platinum(ii) complexes
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc05916a
Abstract: Phosphorescent Pt(II) complexes, composed of a tridentate N^N^C donor ligand and a monodentate ancillary ligand, were covalently attached to DNA oligonucleotides. Three modes of attachment were investigated: positioning the tridentate ligand as an artificial nucleobase… read more here.
Keywords: specific covalent; dna; covalent metalation; ligand ... See more keywords